厚朴提取物、厚朴酚及和厚朴酚的抗氧化和抗衰老药理作用研究进展

厚朴系木兰科植物厚朴Magnolia officinalis或凹叶厚朴M.officinalis Rehd.et Wils.var.biloba的干燥干皮、根皮及枝皮，具有燥湿消痰、下气除满的功效。厚朴提取物、厚朴酚及和厚朴酚都具有抗炎、抗氧化和抗衰老作用，厚朴酚及和厚朴酚是厚朴抗炎、抗氧化和抗衰老的主要活性成分。它们的抗氧化能力是通过对自由基的直接清除作用以及提高机体的抗氧化酶活性间接猝灭自由基表现出来。因此厚朴提取物、厚朴酚及和厚朴酚能防治各种氧化应激性炎性疾病，长期应用可能有防治机体衰老发生发展的作用。综述厚朴提取物、厚朴酚及和厚朴酚的抗氧化和抗衰老药理作用研究进展，以期为抗氧化和抗衰老的新药研发提供依据。

Research advances on antioxidation and anti-aging of extract, magnolol and honokiol from Magnoliae Officinalis Cortex

Magnoliae Officinalis Cortex is dry cortex of trunk, root and branch from Magnolia officinalis or M. officinalis Rehd. et Wils. var. biloba, and have the efficiency of drying dampness to eliminate phlegm, and descending qi to expel fullness. Magnolol and honokiol are extract from Magnoliae Officinalis Cortex, they all have the effects of anti-inflammation, antioxidation and antiaging. Magnolol and honokiol are principal active compositions against inflammation, oxidation and aging in Magnoliae Officinalis Cortex. Their antioxidations are showed by scavenging direct free radical, and eliminating indirect free radical through increasing activity of antioxidases, so extract, magnolol and honokiol from Magnoliae Officinalis Cortex prevent and treat various inflammatory diseases induced by oxidative stress, and their usage with long-term maybe have the actions of preventing and treating for aging. The present paper presents overview of pharmacologic antioxidation and anti-aging of extract, magnolol and honokiol from Magnoliae Officinalis Cortex in order to provides references for the new drug development of antioxidation and antiinflammation.