蛋白质组学在心血管研究中的应用

随着基因组数据库的不断完善和蛋白质组学技术的不断发展，已有越来越多的研究者将蛋白质组学运用到心血管疾病研究中，即运用2—DE、质谱等手段来观察心肌缺血、高血压、心肌肥大、心衰、心肌梗塞导致的心肌细胞蛋白质表达水平和翻译后修饰(PTM)的改变，对这些急慢性心血管疾病的分子机制给予独特的解释。与此同时，各种心血管疾病模型相关蛋白质组数据库也在建设之中，这将大大方便更多的蛋白质组研究。本文综述了近年来使用蛋白质组学在心血管研究中所取得的进展。

Application of proteomics in the research of cardiovascular biology

Along with the completion of genomic database and developments of the skills of proteomics, there are more and more researchers bring proteomics into the research area of cardiovascular diseases. It includes 2 DE and MS to investigate global changes in protein expression level or posttranslational modification (PTM) of cardiomyocytes in response to states of ischemia, hypertension, hypertrophy, failure and infarction, which demonstrate the molecular mechanisms of acute or chronic cardiovascular diseases with unique explanation. Meanwhile, various proteomic data bases that come from corresponding cardiovascular diseases models are on the way of construction, which will be much more convenient for further research. This article reviews the progress of applying proteomics in cardiovascular researches in recent years.