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Molecular networks in respiratory epithelium carcinomas |
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| Authors: | Athanasios G. Pallis Michalis V. Karamouzis Panagiotis A. Konstantinopoulos Athanasios G. Papavassiliou |
| Affiliation: | 1. Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece;2. Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece;3. Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA |
| Abstract: | Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellular networks that participate in respiratory epithelium carcinogenesis have further elucidated the role of a variety of molecules that represent attractive targets for novel therapeutic strategies. The aim of this review is to explore the potential therapeutic opportunities of the manipulation of these pathways. |
| Keywords: | Respiratory epithelium carcinomas EGFR Ras Raf MAPK PI3K Akt JAK STAT PLC PKC |
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