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| 不同类型脑梗死后凝血及纤溶功能的改变 | |
| 引用本文： | 耿直,孙晓江,沈洁,陈静炯,段昊,许丹. 不同类型脑梗死后凝血及纤溶功能的改变[J]. 上海医学, 2010, 33(1) |
| 作者姓名： | 耿直 孙晓江 沈洁 陈静炯 段昊 许丹 |
| 作者单位： | 上海交通大学附属第六人民医院神经内科,200233 |
| 基金项目： | 上海市卫生局科技发展基金资助项目 |
| 摘 要： | 目的 研究不同类型脑梗死后凝血及纤溶系统不同的连续改变.方法 发病48 h内的脑梗死患者136例,分为心源性栓塞性脑梗死(CEI)组(45例)、动脉粥样硬化血栓形成性脑梗死(ATI)组(39例)及腔隙性脑梗死(LI)组(52例),以同期年龄、性别匹配的非脑血管病患者为对照组(38例).测定脑梗死患者发病后48 h内、1周及3周时血浆中凝血酶-抗凝血酶Ⅲ复合物(TAT)、纤维蛋白肽A(FpA)和D-二聚体水平.结果 CEI组患者发病后48 h内、1周及3周时血浆中TAT、FpA和D-二聚体水平均显著高于对照组(P值分别<0.01、0.05).ATI组患者发病后48 h内及1周时血浆中TAT和FpA水平显著高于对照组(P值分别<0.01、0.05),发病后1周及3周时血浆中D-二聚体水平显著高于对照组(P值分别<0.01、0.05).LI组患者不同时间各指标与对照组的差异均无统计学意义(P值均>0.05).结论 不同类型脑梗死后凝血及纤溶系统的改变是不同的,从而为明确脑梗死的发病机制提供一些线索. |
| 关 键 词： | 凝血标志物 脑梗死 血栓形成 纤溶 |
Changes of coagulation and fibrinolysis functions following different subtypes of brain infarction |
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| GENG Zhi,SUN Xiaojiang,SHEN Jie,CHEN Jingjiong,DUAN Hao,XU Dan. Changes of coagulation and fibrinolysis functions following different subtypes of brain infarction[J]. Shanghai Medical Journal, 2010, 33(1) | |
| Authors: | GENG Zhi SUN Xiaojiang SHEN Jie CHEN Jingjiong DUAN Hao XU Dan |
| Affiliation: | GENG Zhi,SUN Xiaojiang,SHEN Jie,CHEN Jingjiong,DUAN Hao,XU Dan.Department of Neurology,Shanghai Sixth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200233,China |
| Abstract: | Objective To study the changes of coagulation and fibrinolytic functions after different types of cerebral infarctions.Methods A total of 136 patients within 48 h of acute ischemic stroke were included in the present study,and they were divided into three subgroups,including 45 with acute cardioembolic infarction(CEI),39 with atherothrombotic infarction(ATI),and 52 with lacunar infarction(LI).Thirty-eight age-and sex-matched non-cerebral vascular patients,who were treated in our hospital during the same per... |
| Keywords: | Coagulation markers Brain infarction Thrombosis Fibrinolysis |
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