乳腺黏液癌MRI表现与免疫组化对照分析

目的探讨35例乳腺黏液癌MRI与免疫组化表现,提高对该病的认识和诊断水平。方法回顾我院经手术病理证实的35例乳腺黏液癌,分析对照MRI表现及免疫组化指标。结果单纯型22例,混合型13例。MRI上表现为肿块22例,非肿块6例,结节状7例;平扫T_1WI低信号24例,等信号9例,混杂高信号2例;T_2WI抑脂高信号15例,稍高混杂信号20例;动态增强早期呈典型环形强化11例;时间信号曲线呈流入型9例,流出型强化9例,平台型强化17例;全部病灶ER、PR、HER-2、Ki-67阳性率分别为91.43%(32/35),68.57%(24/35),28.57%(10/35),62.86%(22/35)。单纯型具有较高的ER、PR阳性率,混合型具有较高的Ki-67、HER-2阳性率;ER、PR与强化形态相关,HER-2与最大径及形状相关,Ki-67与TIC曲线及淋巴结转移相关(P0.05)。结论乳腺黏液癌的MRI表现与免疫组化表现具有一定特征及联系。

Correlation of MRI features and the expression of immunohistochemistry in mucinous breast carcinoma

Objective To investigate the MRI features in correlation with the expression of immunohistochemistry in mucinous breast carcinoma.Methods MRI and the expression of immunohistochemistry of 35 patients with mucinous breast carcinoma confirmed by histopathology were analyzed retrospectively.Results Of 22 pure and 13 mixed mucinous breast carcinoma,22 presented as masses,6 as non-mass,and 7 as nodules.The tumor was T1 hypointense (24),isointense (9),and heterogeneously hyperintense (2).On fat-saturated T2-weighted images,15 were homogeneously and 20 were heterogeneously hyperintense.Dynamic contrast enhancement show typical rim enhancement in 11 cases with wash-in (9),wash-out (9),and plateau (17) patterns of time-signal intensity curves.The tumors were positive for ER (32/35,91.43％),PR (24/35,68.57％),HER-2 (10/35,28.57％),and Ki-67 (22/35,62.86％).Pure tumors had higher positive rates of ER and PR whereas mixed tumors had higher positive rates of HER-2 and Ki-67.ER and PR were correlated with contrast enhancement;HER-2 with maximum lesion diameter and shape;Ki-67 with time-signal intensity curve pattern and lymphatic metastasis.Conclusion MRI features correlate with the expression of immunohistochemistry in mucinous breast carcinoma.