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| 反相高效液相色谱法测定乳酸左氧氟沙星滴眼液含量及其降解产物 | |
| 引用本文： | 陈宁,周学敏,徐群为,郝钦,张勤,谢浩. 反相高效液相色谱法测定乳酸左氧氟沙星滴眼液含量及其降解产物[J]. 药学与临床研究, 1999, 7(4): 13-14 |
| 作者姓名： | 陈宁 周学敏 徐群为 郝钦 张勤 谢浩 |
| 作者单位： | 江苏省药物研究所，江苏省药物研究所，江苏省药物研究所，江苏省药物研究所，江苏省药物研究所，江苏省药物研究所 南京 210009，南京 210009，南京 210009，南京 210009，南京 210009，南京 210009 |
| 摘 要： | 采用反相高效液相色谱法测定乳酸左氧氟沙星滴眼液含量及其降解产物。色谱条件:色谱柱为C_(18)柱;流动相为0.05mol/L柠檬酸溶液-甲醇-乙腈(65:30:5);检测波长294nm;流量为1ml/min;室温。回收率为100.5％(n=6),RSD为0.60％。本色谱条件可用于本品含量测定和降解产物检查。 |
| 关 键 词： | 乳酸左氧氟沙星 乳酸左氧氟沙星滴眼液 反相高效色谱法 |
| 收稿时间： | 1999-04-16 |
Determination of Levofloxacin Lactate and its Degradation Products in Levofloxcin Lactate Eye Drops by RP-HPLC |
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| Chen Ning,Zhou xuemin,Xu qunwiei,Hao qing,Zhang Qin and Xie Hao. Determination of Levofloxacin Lactate and its Degradation Products in Levofloxcin Lactate Eye Drops by RP-HPLC[J]. Pharmacertical and Clinical Research, 1999, 7(4): 13-14 | |
| Authors: | Chen Ning Zhou xuemin Xu qunwiei Hao qing Zhang Qin Xie Hao |
| Affiliation: | Nanjing 210009 |
| Abstract: | Levofloxacin Lactate and its degradation products in levofloxacin lactate eye drops were determined by RP-HPLC. Column; C18(3.9mm×300mm), mobile phase : 0.05mol/L citric acid-methanol-acetomtrile (65:30:5);UV detector wavelength 294nm,flow rate: 1ml/min,room temperature. The average recovery was 100.5%(n=6) RSD was 0.60%. The degradation products were determined. |
| Keywords: | Levofloxacin lactate Levofloxacin lactate eye drops RP-HPLC |
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