吡非尼酮的药理学及疾病治疗学研究进展

吡非尼酮是近年来上市用于治疗特发性肺纤维化的药物。研究证实该药具有抑制胶原合成、抗炎和抗氧化的作用。吡非尼酮作为一种广谱的抗纤维化药物,在特发性肺纤维化、肝纤维化、肾纤维化、心脏组织纤维化、多发性硬化症、神经纤维瘤、子宫肌瘤、恶性胶质瘤的治疗和器官移植纤维化的预防方面均具有广阔的应用前景。

Progress in pharmacology and clinical applications of pirfenidone

The recently - marketing drug pirfenidone is for the treatment of idiopathic pulmonary fibrosis. The drug has been proved to be active in the inhibition of collagen synthesis, and in anti - inflammatory and antioxidant actions. As a broad - spectrum antiflbrotic drug, pirfenidone would play an important role in the treatment of idiopathic fibrosis of the lung, hepatic fibrosis, kidney fibrosis, myocardial fibrosis, multiple sclerosis, neurofibroma, uterine leiomyoma and malignant glioma, and in the prevention of organ transplantation fibrosis.