| HLA-A26等位基因与银屑病环境危险因素的交互作用 |
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| 引用本文： | 高敏,张学军,魏生才,杨森,崔勇.HLA-A26等位基因与银屑病环境危险因素的交互作用[J].中国麻风皮肤病杂志,2003,19(1):22-24. |
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| 作者姓名： | 高敏 张学军 魏生才 杨森 崔勇 |
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| 作者单位： | 安徽医科大学第一附属医院皮肤科,合肥,230022 |
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| 基金项目： | 安徽省自然科学基金项目 |
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| 摘 要： | 目的：研究银屑病HLA－A26等位基因与环境危险因素之间的交互作用。方法：采用病例对照研究方法，调查190例银屑病患者及同一地区的健康对照191例，用多聚酶链反应－序列特异性引物（PCR－SSP）方法进行HLA－A26等位基因检测，对银屑病的环境危险因素及与HLA－A等位基因间交互作用进行研究。结果：（1）受潮、感染、外伤、嗜酒、吸烟、食鱼虾、药物和精神紧张均为银屑病的环境危险因素。（2）与正常对照组相比，HLA－A26等位基因与银屑病呈显著正相关（P＜0．001）。（3）HLA－A26等位基因与受潮、嗜酒和食鱼虾存在显著交互作用。结论：HLA－A26等位基因似能增加受潮、嗜酒和食鱼虾发生银屑病的易患性。
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| 关 键 词： | HLA－A26等位基因 银屑病 环境危险因素 交互作用 |
A study on the interaction between HLA- A26 allele and environmental risk factors in psoriasis |
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| Gao Min,Zhang Xuejun,Wei Shengcai,et al..A study on the interaction between HLA- A26 allele and environmental risk factors in psoriasis[J].China Journal of Leprosy and Skin Diseases,2003,19(1):22-24. |
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| Authors: | Gao Min Zhang Xuejun Wei Shengcai |
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| Institution: | Gao Min,Zhang Xuejun,Wei Shengcai,et al. Institute of Dermatology,The first Affiliated Hospital of Anhui Medical University,Hefei,230032 |
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| Abstract: | Objective:To study the interaction between HLA-A26 allele and environmental risk factors in psoriasis.Methods: A case-control study was designed. One hundred and ninety psoriatic patients and 191 healthy people were investigated. The HLA-A26 allele was examined by PCR-SSP. Results: (1) Moisture, infection, smoking, drinking, eating fish and shrimp, consumption of drugs and stress were the environmental risk factors in psoriasis. (2) The HLA-A26 allele was associated with psoriasis. (3) An interaction was found between HLA-A26 allele and moisture, drinking and eating fish and shrimp. Conclusion : The HLA-A26 allele increases the liability of patients to the moisture, drinking, and eating fish and shrimp in psoriasis. |
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| Keywords: | psoriasis environmental factors HLA-A26 alleles interaction |
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