Low interleukin-2 receptor levels in serum of patients with insulin-dependent diabetes |
| |
Authors: | R Wagner E Bonifacio P J Bingley S Genovese D Reinwein G F Bottazzo |
| |
Institution: | (1) Department of Immunology, London Hospital Medical College, London, UK;(2) Department of Medicine, San Raffaele Hospital Scientific Institute, Milan, Italy;(3) Department of Diabetes and Metabolism, St. Bartholomew's Hospital Medical College, London, UK;(4) Abteilung für Endokrinologie, Medizinische Klinik und Poliklinik, Universitätsklinikum, Hufelandstrasse 55, D-45122 Essen, Germany |
| |
Abstract: | Interleukin-2 receptors are released in the circulation in response to antigenic or mytogenic stimulation of T-lymphocytes. Abnormal serum interleukin-2 receptor levels have been found in young children with type 1 diabetes and prediabetes. We measured interleukin-2 receptor levels in 17 patients with newly diagnosed type 1 diabetes, 21 patients with long-standing type 1 diabetes, 19 patients with long-standing type 2 diabetes, 19 islet-cell antibody positive nondiabetic polyendocrine patients, 12 islet-cell antibody-positive first-degree relatives of patients with type 1 diabetes and compared the results to age- and sex-matched normal controls. We found significantly lower interleukin-2 receptor levels in patients with newly diagnosed and long-standing type 1 diabetes compared to normal controls (87 ± 11 and 93 ± 11 vs. 142 ± 25 and 132 ± 40 U/ml, P < 0.001 and P < 0.01). There were no significant differences in interleukin-2 receptor levels between prediabetic groups and normal controls or patients with long-standing type 1 or type 2 diabetes. There was no correlation between glycosylated hemoglobin, blood glucose levels, and interleukin-2 receptor in the groups with long-standing type 1 or type 2 diabetes. We conclude that patients with type 1 diabetes have low interleukin-2 receptor serum levels. This phenomenon is acquired close to disease onset and is unlikely to be an early markers of type 1 diabetes.Abbreviations JDf
Juvenile Diabetes foundation
- ICA+
islet-cell antibody positive
- IDDM
insulin-dependent diabetes mellitus
- IL-2R®
interleukin-2 receptors
- NIDDM
non-insulin-dependent diabetes mellitus
Correspondence to: R. Wagner |
| |
Keywords: | Soluble interleukin-2 receptors Type 1 diabetes Type 2 diabetes Prediabetes Autoimmune polyendocrinopathy |
本文献已被 SpringerLink 等数据库收录! |
|