| 基质金属蛋白酶-9预测胎儿宫内生长受限的意义 |
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| 引用本文： | 顾京红,黄亚绢,罗来敏,郑哲. 基质金属蛋白酶-9预测胎儿宫内生长受限的意义[J]. 中国优生与遗传杂志, 2010, 0(1): 31-32 |
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| 作者姓名： | 顾京红 黄亚绢 罗来敏 郑哲 |
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| 作者单位： | 上海交通大学附属第六人民医院妇产科; |
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| 摘 要： | 目的探讨基质金属蛋白酶-9(MMP-9)与胎儿宫内生长受限(FGR)的关系及其预测FGR的意义。方法回顾性分析了自2006年9月至2008年10月在上海市第六人民医院分娩的部分孕妇,其中FGR组29例,正常组41例。于孕28周时抽取母体静脉血,分离血清后放置冰箱待用,于足月分娩时同时抽取母静脉血及脐静脉血,分离血清,用ELISA法测定血清中MMP-9浓度。结果FGR组脐血及母血MMP-9的浓度均低于正常组(分别为1.76±0.22*,1.50±0.20△+);而且,孕28周时母血的MMP-9高于足月分娩时母血中的MMP-9;脐血中MMP-9浓度明显高于母血中的浓度(P0.01),脐血与母血中MMP-9浓度无相关性(P0.05)。结论MMP-9与FGR有关,早期检测基质金属蛋白酶(MMP-9)有助于预测FGR;母体静脉血不能完全替代脐静脉血中MMP-9浓度的检测。
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| 关 键 词： | 胎儿宫内生长 基质金属蛋白酶-9 |
A study on the relationship between MMP-9 and Fetal growth restriction |
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| GU Jing -hong,HUANG Ya -juan,LUO Lai - ming,ZHENG zhe. A study on the relationship between MMP-9 and Fetal growth restriction[J]. Chinese Journal of Birth Health & Heredity, 2010, 0(1): 31-32 |
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| Authors: | GU Jing -hong HUANG Ya -juan LUO Lai - ming ZHENG zhe |
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| Affiliation: | . ( Department of Obstetrics and Gynecology, Affiliated to the Sixth People＇s Hospital, Shanghai Jiaotong University, Shanghai 200233) |
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| Abstract: | Objetive:To investigate the relationship between MMP-9 and fetal growth restriction(FGR).Methods:Restropectively,the samples of maternal blood and matched umbilical cord blood were collected from 29 patients of FGR and 41 normal pregnant women who delivered in our hospital.The level of MMP-9 in the samples was analyzed by ELLISA.Results:The level of MMP-9 in umbilical serum and maternal serum of FGR group was significantly lower than that of normal group.The level of MMP-9 in umbilical serum,moreover,was si... |
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| Keywords: | Fetal Growth Retardation Matrix metalloproteinases-9 |
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