| Integrinα4在骨肉瘤中的表达与意义 |
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| 作者姓名： | LUO Zhengqiang CHEN Anmin GUO Fengjin LI Xinzhi |
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| 作者单位： | Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China |
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| 摘 要： | Objective： To investigate the expression of integrin α4 in osteosaxcoma and significance. Methods- Forty-six patients with osteosarcoma （Enneking Ⅰ-Ⅲ） were analyzed for the expression of α4 integrin subunit using immunohistochemical method. Results： Twenty-nine （63.04%） of 46 samples demonstrated positive （＋-＋＋） integrin α4 expression. Loss expression of integrin α4 was observed in the patients with advanced Enneking stage （P=0.0040） and with metastatic disease at presentation （P=0.0158）. Integrin α4 expression correlated with cell differentiation, the level of malignancy and the invasive behavior of osteosaxcoma. Conclusion： The loss expression of integrin α4 subunit might be a predictor indicating the invasive potential of osteosarcoma and play a role in metastasis of osteosaxcoma patients.
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| 关 键 词： | 整联蛋白α4 骨肉瘤 基因表达 病理机制 |
| 收稿时间： | 2005-06-01 |
| 修稿时间： | 2005-07-07 |
Expression of Integrin α4 in Osteosarcoma and Significance |
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| LUO Zhengqiang CHEN Anmin GUO Fengjin LI Xinzhi.Expression of Integrin α4 in Osteosarcoma and Significance[J].The Chinese-German Journal of Clinical Oncology,2006,5(2):138-140. |
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| Authors: | Zhengqiang LUO Anmin CHEN Fengjin GUO Xinzhi LI |
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| Institution: | (1) Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
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| Abstract: | Objective: To investigate the expression of integrin α4 in osteosarcoma and significance. Methods:
Forty-six patients with osteosarcoma (Enneking I-III) were analyzed for the expression of α4 integrin
subunit using immunohistochemical method. Results: Twenty-nine (63.04%) of 46 samples demonstrated
positive (+-++) integrin α4 expression. Loss expression of integrin α4 was observed in the patients with
advanced Enneking stage (P=0.0040) and with metastatic disease at presentation (P=0.0158). Integrin
α4 expression correlated with cell differentiation, the level of malignancy and the invasive behavior of
osteosarcoma. Conclusion: The loss expression of integrin α4 subunit might be a predictor indicating the
invasive potential of osteosarcoma and play a role in metastasis of osteosarcoma patients. |
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| Keywords: | liver neoplasms carcinoma hepatocellular loss of heterozygosity microsatellite instability allelic imbalance |
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