| Effects of sodium ferulate on the ultrarapid delayed rectifier K^＋ current in human atrial myocytes |
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| 作者单位： | Xiang Gao（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Kun Liu（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Jinping Liu（Department of Cardiac surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Yanfu Wang（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Changwei Zhang （Department of Cardiac surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Zhijian Chen（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Qiutang Zeng（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ;Yuhua Liao（Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China） ; |
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| 摘 要： | Objective To study the effects of sodium ferulate on the ultrarapid delayed rectifier K current(Ikur) in human atrial myocytes.MethodsHuman atrial myocytes were isolated by enzyme dispersion method. Ikur in human atrial myocytes were recorded by using the whole cell patch clamp. The changes of Ikur were compared in the absence and the presence of sodium ferulate. ResultsThere was no effect of 0.4 g/L sodium ferulate on I-V relation of Ikur However, 0.4 g/L sodium ferulate inhibited Ikur to some degrees at each test pulse. The current densities of Ikur at 60 mV decreased from 4.997 ± 0.35 PA/PF to 3.331 ± 0.26 PA/PF(n = 6, P ＜ 0.05). The inhibitory effect was concentration-dependent. IC50 was(0.41 ± 0.03)g/L and the Hill coefficient was 0.95 ± 0.05. ConclusionSodium ferulate as a potassium channel blocker can inhibit Ikur in human atrial myocytes effectively.
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| 关 键 词： | 膜片箝 阿魏酸钠 超高速整流器 肌细胞 |
| 收稿时间： | 2007-07-25 |
Effects of sodium ferulate on the ultrarapid delayed rectifier K current in human atrial myocytes |
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| Xiang Gao,Kun Liu,Jinping Liu,Yanfu Wang,Changwei Zhang,Zhijian Chen,Qiutang Zeng,Yuhua Liao. Effects of sodium ferulate on the ultrarapid delayed rectifier K current in human atrial myocytes[J]. Journal of Nanjing Medical University, 2008, 22(1): 1-4 |
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| Authors: | Xiang Gao Kun Liu Jinping Liu Yanfu Wang Changwei Zhang Zhijian Chen Qiutang Zeng Yuhua Liao |
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| Abstract: | Objective: To study the effects of sodium ferulate on the ultrarapid delayed rectifier K current(Ikur) in human atrial myocytes.Methods:Human atrial myocytes were isolated by enzyme dispersion method. Ikur in human atrial myocytes were recorded by using the whole cell patch clamp. The changes of Ikur were compared in the absence and the presence of sodium ferulate. Results:There was no effect of 0.4 g/L sodium ferulate on I-V relation of Ikur However, 0.4 g/L sodium ferulate inhibited Ikur to some degrees at each test pulse. The current densities of Ikur at 60 mV decreased from 4.997 ± 0.35 PA/PF to 3.331 ± 0.26 PA/PF(n = 6, P ＜ 0.05). The inhibitory effect was concentration-dependent. IC50 was(0.41 ± 0.03)g/L and the Hill coefficient was 0.95 ± 0.05. Conclusion:Sodium ferulate as a potassium channel blocker can inhibit Ikur in human atrial myocytes effectively. |
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| Keywords: | sodium ferulate ultrarapid delayed rectifier K current patch clamp |
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