| 489例不良孕产史患者细胞遗传学分析 |
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| 引用本文： | 陈咏健,杨丽萍,高雪峰,周羡梅.489例不良孕产史患者细胞遗传学分析[J].中国优生与遗传杂志,2005,13(5):42-44. |
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| 作者姓名： | 陈咏健 杨丽萍 高雪峰 周羡梅 |
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| 作者单位： | 北京大学第三医院妇产科,100083 |
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| 摘 要： | 目的探讨染色体异常对生育的影响.方法对489例有自然流产、胎停育或生育畸形儿史的患者进行外周血淋巴细胞培养,G显带染色体核型分析.结果 489例患者中染色体核型异常24例, 异常率达4.9%, 其中有自然流产、胎停育史的患者核型异常占20例,有生育畸形儿史的患者核型异常占4例.染色体变异共21例,占4.3%.结论染色体异常是导致不良生育的重要影响因素, 应重视遗传学检查,进行优生优育指导.
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| 关 键 词： | 细胞遗传学分析 不良孕产史 患者 外周血淋巴细胞培养 染色体核型分析 染色体核型异常 染色体异常 生育畸形儿 自然流产 染色体变异 遗传学检查 不良生育 优生优育 胎停育 G显带 异常率 |
| 文章编号： | 1006-9534(2005)-05-0042-03 |
| 修稿时间： | 2004年11月14 |
Analysis of chromosomal karyotypes in 489 patients with badness pregnancy history |
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| CHEN Yong-jian,YANG Li-ping,GAO Xue-feng,et al..Analysis of chromosomal karyotypes in 489 patients with badness pregnancy history[J].Chinese Journal of Birth Health & Heredity,2005,13(5):42-44. |
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| Authors: | CHEN Yong-jian YANG Li-ping GAO Xue-feng |
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| Abstract: | Objective:To study the effect of chromsosmal abnormalities on pregnacy. Methods: Chromosomal karyotypes were examined in 489 patients with spontaneous abortion or embryo growth ceasing or bearing malformation child history by periphery blood lymphocyte culture and G banding. Results: Chromosomal abnormalities were checked out in 24 patients (4.9%), including 20 patients with spontaneous abortion or embryo growth ceasing and 4 patients with bearing malformation child history. Conclusion: Chromosomal abnormalities play an important role in badness pregnancy. |
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| Keywords: | Chromosomal karyotypes Spontaneous abortion Malformation child |
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