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| 延胡索物质基础研究 | |
| 引用本文： | 杨鑫宝,杨秀伟,刘建勋. 延胡索物质基础研究[J]. 中国中药杂志, 2014, 39(1): 20-27 |
| 作者姓名： | 杨鑫宝 杨秀伟 刘建勋 |
| 作者单位： | 中国中医科学院 西苑医院 实验研究中心, 北京 100091;北京中医药大学, 北京 100029;北京大学 天然药物及仿生药物国家重点实验室, 药学院 天然药物学系, 北京 100191;北京大学 天然药物及仿生药物国家重点实验室, 药学院 天然药物学系, 北京 100191;中国中医科学院 西苑医院 实验研究中心, 北京 100091;北京中医药大学, 北京 100029 |
| 基金项目： | 国家自然科学基金重点项目（30830118）；国家“十二五”科技支撑计划项目（2011BAI07B08） |
| 摘 要： | 延胡索是常用传统中药之一，主要化学成分为原小檗碱类和阿朴啡类生物碱。该文概述延胡索所含生物碱成分的研究，分析其结构类型及新的定性、定量方法；分析其生物转化、吸收、分布、代谢、排泄、药代动力学、药物相互作用等特点，为确定延胡索的药效物质基础提供科学依据。 |
| 关 键 词： | 延胡索 生物碱 药效物质基础 |
| 收稿时间： | 2013-04-13 |
Study on material base of Corydalis Rhizoma |
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| YANG Xin-bao,YANG Xiu-wei and LIU Jian-xun. Study on material base of Corydalis Rhizoma[J]. China Journal of Chinese Materia Medica, 2014, 39(1): 20-27 | |
| Authors: | YANG Xin-bao YANG Xiu-wei LIU Jian-xun |
| Affiliation: | Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Beijing University of Chinese Medicines, Beijing 100029, China;State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Beijing University of Chinese Medicines, Beijing 100029, China |
| Abstract: | Corydalis Rhizoma, the dried tuber of Corydalis yanhusuo (Papaveraceae) distributed traditionally mainly in southeastern and now cultivated in northwestern and other district in China, is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain, abdominal pain, pain due to injury, and promote blood circulation. Its main chemical constituents were alkaloids, which were divided into the two types of protoberberines and aporphines. Among them, some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system, which plays an important role in regulating nociception. In this article, the chemical composition and structure-types, new methods of qualitative and quantitative analysis as well as characteristics of biotransformation, absorption, distribution, metabolism, excretion, pharmacokinetic, and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma. |
| Keywords: | dried tuber of Corydalis yanhusuo alkaloid bioactive material base |
| 本文献已被 CNKI 等数据库收录！ | |