非小细胞肺癌FHIT基因蛋白表达缺失及与突变型p53表达相关性

目的]了解非小细胞肺癌组织(NSCLC)中脆性组氨酸三联体(FHIT)基因蛋白(Fhit)表达缺失及其与突变型p53基因蛋白(p53)表达的相关性.方法]应用免疫组织化学方法了解NSCLC组织中Fhit及p53的表达.结果]62.2%(56/90)的NSCLC组织显示Fhit表达缺失,同时48.9%(44/90)有突变型p53表达;两者的异常表达在非鳞组中明显相关(P＜0.001),而在鳞癌组中无相关性(P=0.079);另外,两者的异常表达在非吸烟组中明显相关(P=0.006),而在吸烟组中无相关性(P=0.113).结论]Fhit表达缺失和突变型p53表达是NSCLC中常见事件;而且两者在non-SqCC和非吸烟的肺癌者中有明显的相关性.

Negative Expression of FHIT and Its Correlation with Mutated p53 Expression in Non-small Cell Lung Carcinoma

To investigate the negative expression of Fragile Histidine Triad gene protein (Fhit) and its correlation with mutated p53 gene protein(p53) expression in non-small cell lung carcinomas(NSCLC). Fhit and p53 expressions in NSCLC tissues were detected by immunohistochemistry method. 56 in 90 (62.2%) NSCLC showed absence of Fhit and 44 in 90 (48.9%) showed mutation expression of p53. Fhit and p53 abnormalities showed close correlation in non-squamous cell cancer(P<0.001),but showed no correlation in squamous cell cancer(P=0.079);while,Fhit and p53 abnormalities showed close correlation in non-smokers(P=0.006),but showed no correlation in smokers(P=0.113). Conclusions] Negative expression of Fhit and mutation expression of p53 are frequent events in NSCLC. Moreover, there is a significant relationship between Fhit negative expression and mutated p53 expression in non-SqCC and non-smokers.