蟾酥化学成分及药理活性研究进展

蟾酥作为一种重要的传统中药,其化学成分复杂,临床用途较广。通过对蟾酥化学成分的分离和鉴定,已确定其主要的化学成分包括蟾蜍内酯类、吲哚类生物碱、甾醇类等化合物。随着国内外对蟾酥越来越深入的研究,其化学成分的药理活性机制也日益清晰,主要被用于抗肿瘤、强心、抗菌、镇痛等方面,甚至用于局部麻醉,且治疗效果显著。对蟾酥的化学成分、药理作用等方面进行综述,为蟾酥的临床安全合理应用提供参考。

Research progress on chemical constituents and pharmacological activities of Bufonis Venenum

Bufonis Venenum, as an important Chinese traditional natural medicine, has complex chemical composition and has been widely used in clinical treatment with significant effects. The chemical constituents in Bufonis Venenum mainly included bufadienolides, indole alkaloids, steriods, etc. With the further research on Bufonis Venenum both at home and abroad, its chemical composition and mechanism of pharmacological activities have been more and more clearly, especially in the aspects of narcotic analgesic, cardiac, and antitumor therapy. This paper reviewed the chemical composition and pharmacology advances of Bufonis Venenum in order to provide reference to clinical use.