益气活血方对性激素致大鼠子宫增生的影响

目的?观察益气活血方对实验性大鼠子宫增生的抑制作用。方法?将3月龄未孕雌性大鼠随机分为空白对照组、模型对照组、阳性给药组0.465g/(kg·d)、益气活血方高剂量给药组40g/(kg·d)、低剂量给药组10g/(kg·d)。用苯甲酸雌二醇加黄体酮肌肉注射方法对模型对照组、阳性给药组、益气活血方高、低剂量给药组进行子宫肌瘤模型的复制，1周后同时对给药组分别灌胃给予受试药益气活血方和阳性对照药桂枝茯苓胶囊，5周后测各组的血液流变学指标，解剖大鼠取出子宫，计算子宫系数，并对子宫进行病理组织形态学观察。结果?益气活血方能抑制模型大鼠子宫的扩大及瘤样增生和改善血凝状态。结论?益气活血方具有预防和治疗子宫肌瘤的作用。 

Effects of Yiqi Huoxue Fang on Hysteromyoma Rats Caused by Gonadal Hormone

OBJECTIVE To investigate the effects of Yiqi Huoxue Fang(YQHXF) on the experimental model of uterine leiomyoma in rat.METHODS 70 Wistar unpregnancy 3-month-old female rats were randomly divided into 3 groups:model group,positive control group,therapy group.Estradiol benzoate and progesterone were administrated by intramuscular injection once a day to establish rat hysteromyma model,one week later YQHXF of different concentrations(40g/kg,10g/kg) and Guizhi Fuling capsule(GFC) as positive medicine(0.465g/kg) ...