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| 荧光原位杂交技术检测非小细胞肺癌EGFR基因扩增 | |
| 引用本文： | 王晓敏,李军,袁勇,王一羽. 荧光原位杂交技术检测非小细胞肺癌EGFR基因扩增[J]. 临床与实验病理学杂志, 2011, 27(11) |
| 作者姓名： | 王晓敏 李军 袁勇 王一羽 |
| 作者单位： | 陕西省肿瘤医院病理科,西安,710061 |
| 摘 要： | 目的探讨荧光原位杂交(FISH)技术检测非小细胞肺癌(non-small cell lung cancer,NSCLC)表皮生长因子受体(epider-mal growth factor receptor,EGFR)基因扩增的临床应用价值。方法采用FISH技术检测57例人NSCLC石蜡组织标本中EG-FR基因扩增水平。对于EGFR基因扩增阳性的患者采用酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)药物进行治疗,其余患者采用传统化疗进行治疗。结果 57例NSCLC患者中有18例EGFR基因扩增阳性(31.58%),其中12例为高多体性扩增(66.67%),5例为成簇扩增(27.78%),以肺腺癌为主(72.22%)。TKIs靶向药物治疗有效率(RR)、中位生存时间(MST)和1年生存率分别为61.11%1、3.5个月和55.56%,对照组分别为35.89%、7.6个月和33.33%,差异均有显著性(P<0.05),前者的疾病控制率(DCR)高于后者,但差异无统计学意义(P>0.05)。结论使用FISH技术检测NSCLC患者EG-FR基因扩增水平可以为临床采用TKIs药物治疗提... |
| 关 键 词： | 肺肿瘤 非小细胞肺癌 表皮生长因子受体 荧光原位杂交 酪氨酸激酶抑制剂 |
Fluorescence in situ hybridization technique for detection of EGFR gene amplification of non-small cell lung cancer and clinical value |
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| WANG Xiao-min,LI Jun,YUAN Yong,WANG Yi-yu. Fluorescence in situ hybridization technique for detection of EGFR gene amplification of non-small cell lung cancer and clinical value[J]. Chinese Journal of Clinical and Experimental Pathology, 2011, 27(11) | |
| Authors: | WANG Xiao-min LI Jun YUAN Yong WANG Yi-yu |
| Affiliation: | WANG Xiao-min,LI Jun,YUAN Yong,WANG Yi-yu (Department of Pathology,Cancer Research Laboratory,Shanxi Province Cancer Hospital,Xi'an 710061,China) |
| Abstract: | Purpose To investigate the clinical application value of fluorescence in situ hybridization(FISH) technique for the detection of EGFR gene amplification in patients with non-small cell lung cancer(NSCLC).Methods The EGFR gene amplification in the tissue samples from 57 patients with NSCLC were detected by FISH.The patients with EGFR gene amplification positive and negative were treated with tyrosine kinase inhibitors(TKIs) and the others were treated with conventional chemotherapy treatment respectively.Res... |
| Keywords: | lung cancer non-small cell lung cancer epidermal growth factor receptor fluorescence in situ hybridization tyrosine kinase inhibitors |
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