|
|||||
|
|
| 骨巨细胞瘤中Skp2、p27及E2F-1的表达及意义 | |
| 引用本文： | 李翀,李海,冯一中. 骨巨细胞瘤中Skp2、p27及E2F-1的表达及意义[J]. 临床与实验病理学杂志, 2011, 27(11) |
| 作者姓名： | 李翀 李海 冯一中 |
| 作者单位： | 1. 江苏省昆山市第一人民医院骨科,昆山,215300 2. 江苏省昆山市第一人民医院病理科,昆山,215300 3. 苏州大学附属第二医院病理科,苏州,215004 |
| 基金项目： | 昆山市科技局科研立项(KS1004) |
| 摘 要： | 目的研究骨巨细胞瘤中Skp2(S期激酶相关蛋白2)、p27(周期素依赖性蛋白激酶抑制因子)及E2F-1(细胞周期相关性转录因子家族成员)的表达并探讨其与放射学分期、肿瘤复发等关系。方法运用免疫组化SP法检测44例骨巨细胞瘤中Skp2、p27及E2F-1的表达情况。结果 Skp2、p27及E2F-1的阳性率分别为65.91%3、8.64%和63.64%,在影像学分期1型、2型3、型中的阳性率分别为50%、64.29%、100%(P<0.05),60%、28.57%、10%(P<0.05),50%、71.43%、80%(P>0.05)。Skp2、p27及E2F-1在复发组与未复发组的阳性率分别为91.67%、56.25%(P<0.05),8.33%、50%(P<0.05),75.00%、59.38%(P>0.05)。Skp2、骨皮质破坏或软组织浸润、手术方式以及p27对复发均有明显影响,其中前两者是骨巨细胞瘤复发的危险因素,后两者(截骨的手术方式、p27)则是骨巨细胞瘤复发的保护因素。Skp2与p27的表达呈负相关(P<0.05)。结论在骨巨细胞瘤中,Skp2与p27的表达均与骨巨细胞瘤的复发有关,二者在骨巨细胞... |
| 关 键 词： | 骨巨细胞瘤 Skp2 p27 E2F-1 免疫组化 |
The expression and significance of Skp2,p27 and E2F-1 in giant cell tumor of bone |
|
| LI Chong,LI Hai,FENG Yi-zhong. The expression and significance of Skp2,p27 and E2F-1 in giant cell tumor of bone[J]. Chinese Journal of Clinical and Experimental Pathology, 2011, 27(11) | |
| Authors: | LI Chong LI Hai FENG Yi-zhong |
| Affiliation: | LI Chong1,LI Hai2,FENG Yi-zhong3 (Department of 1Orthopedics,2Pathology,the First People's Hospital of Kunshan,Jiangsu Province,Kunshan 215300,China,3Department of Pathology,the Second Affiliated Hospital of Suzhou University,Suzhou 215004,China) |
| Abstract: | Purpose To study the expression of Skp2,p27 and E2F-1 protein in giant cell tumor of bone(GCT) and detect the correlation between their expression and radiological stage,tumor recurrence.Methods Immunohistochemical SP staining method was used to detect the expression of Skp2,p27 and E2F-1 in 44 cases of GCT.Results The positive rate of Skp2,p27 and E2F-1 were 65.91%,38.64% and 63.64%,respectively.According to radiological stage(stage 1,2 and 3),the positive rate of Skp2,p27 and E2F-1 were 50%,64.29%,100%(P<... |
| Keywords: | giant cell tumor of bone Skp2 p27 E2F-1 immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |