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| 大蒜素对人膀胱癌细胞BIU-87增殖和凋亡影响 | |
| 引用本文： | 王锋,伍静. 大蒜素对人膀胱癌细胞BIU-87增殖和凋亡影响[J]. 四川生理科学杂志, 2011, 33(3): 104-105 |
| 作者姓名： | 王锋 伍静 |
| 作者单位： | 1. 四川省隆昌县人民医院泌尿外科 2. 四川省隆昌县人民医院妇产科,四川,隆昌,642150 |
| 摘 要： | 目的:观察大蒜素对人膀胱癌细胞BIU-87增殖和凋亡的影响。方法:采用细胞计数法(Cell counting kit-8,CCK-8)检测不同浓度的大蒜素对BIU-87细胞生长的影响;流式细胞仪AnnexinV/PI双染法检测BIU-87细胞的凋亡率。结果:大蒜素作用于BIU-87细胞后,对其增值表现出了明显的抑制作用,且呈浓度依赖性;AnnexinV/PI双染法检测显示,不同浓度的大蒜素均可诱导BIU-87细胞凋亡,与阴性对照组比较,差异有统计学意义(P<0.05)。结论:大蒜素可抑制BIU-87细胞的增殖,诱导其凋亡。 |
| 关 键 词： | 大蒜素 膀胱癌 凋亡 |
Effects of Allicin on proliferation and apoptosis of BIU-87 |
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| Wang Feng,Wu Jing. Effects of Allicin on proliferation and apoptosis of BIU-87[J]. Sichuan Journal of Physiological Sciences, 2011, 33(3): 104-105 | |
| Authors: | Wang Feng Wu Jing |
| Affiliation: | 1. Department of Urology, The People＇s Hospital of Sichuan Longchang; 2. Department of Obstetrics and Gynecology, The People＇s Hospital of Sichuan Longchang, Sichuan Longchang, 646000) |
| Abstract: | Objective： To investigate the effects of Allicin on proliferation and apoptosis of BIU-87. Methods： Growth inhibition was measured by cell counting kit-8, the rate of apoptosis was detected by flow cytometry with Annexin-V/PI staining. Results： Allicin effectively inhibited the growth of BIU-87 in a concentration-dependent manner. Compared with the negative control group, the apoptosis of BIU-87 was significantly induced by different concentration of Allicin （P〈0. 05）. Conclusion： Allicin can inhibit the proliferation and induce apoptosis of BIU-87. |
| Keywords: | Allicin Bladder cancer Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |