老年糖尿病肾病与炎性因子的关系

目的探讨老年糖尿病肾病与炎症因子的关系。方法选择老年科门诊及住院的老年2型糖尿病患者96例，根据尿白蛋白排泄率分为3组：正常蛋白尿组19例，UAER〈20μg／min；微量蛋白尿组，UAER20～200μg／min；临床蛋白尿组，UAER〉200μg／min。抽取空腹静脉血，分别测定3组患者血清TNF—α、IL-6、C-RP的含量，用放射免疫分析测定血清肿瘤坏死因子、白介素-6（IL-6）的含量，用透射比浊法测定C反应蛋白（RP）。结果3组血清TNF-α、IL-6、CRP的含量有显著差异（P〈0．05），微量蛋白尿组和临床蛋白尿组的血清TNF-α、IL-6、CRP的含量明显高于正常蛋白尿组（P〈0．05），并随着糖尿病肾病程度的加重而逐步升高。结论炎性反应可能参与了糖尿病肾病的发生发展，对炎性因子的监测有益于老年糖尿病肾病的诊治。

Relationship between inflammation tactors and diabetic nephropathy in elderly patients

Objective To explore the relationship between inflammation factors and diabetic nephropathy in elderly patients. Methods A total of 96 elderly patients with type 2 diabetes mellitus were enrolled in the study. All the patients were divided into three groups according to urinary albumin excretion rate： normal proteinuria group （UAER 〈 20μg,/min）, mieroalbuminuria group （ UAER20-200μg/min ） and clinical proteinuria group （ UAER 〉 200μg/min ）. The fasting venous blood specimens of all the patients were taken out, then the serum levels of tumor necrosis factor-or （ TNF-α）, interleukin-6 （IL-6） were detected by radio-immunity assay and the serum levels of C-reactive protein （CRP） were detected by turbidimetry. Results There were significant differences in the serum levels of TNF-α, IL-6, CRP among the three groups. The serum levels of TNF-α, IL-6, CRP in microalbuminuria group and clinical proteinuria group were significantly higher than those in normal proteinuria group （ P 〈 0.05 ）, moreover, which increased with the aggravation of diabetic nephropathy degree. Conclusion Inflammation factors may be involved in the pathogenesis and development of diabetic nephropathy, and the detection of these inflammation factors is helpful for diagnosis and treatment of diabetic nephropathy in elderly patients.