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| THE STUDY OF INTERRELATION BETWEEN HUMAN PAPILLOMAVIRUS INFECTION AND LANGERHANS CELL IN THE CARCINOGENESIS OF ESOPHAGEAL CARCINOMA | |
| 引用本文： | 张云汉,李静,高冬玲,乔思杰,文小岗. THE STUDY OF INTERRELATION BETWEEN HUMAN PAPILLOMAVIRUS INFECTION AND LANGERHANS CELL IN THE CARCINOGENESIS OF ESOPHAGEAL CARCINOMA[J]. 郑州大学学报(医学版), 1997, 0(3) |
| 作者姓名： | 张云汉 李静 高冬玲 乔思杰 文小岗 |
| 作者单位： | 河南医科大学第一附属医院病理科河南省肿瘤病理学重点实验室，河南省肿瘤医院病理科 |
| 摘 要： | 为了解人乳头瘤病毒（ＨＰＶ）对免疫Ｌａｎｇｅｒｈａｎｓ细胞（ＬＣ）的影响及ＨＰＶ的致癌机理，采用地高辛配基标记的ＨＰＶ１６／１８ＤＮＡ探针和抗Ｓ１００蛋白抗体，分别用原位分子杂交和免疫组化ＬＳＡＢ法，检测了４０例食管鳞状细胞癌中ＨＰＶＤＮＡ序列及分布，重点观察了ＨＰＶ感染时局部癌旁上皮内Ｓ１００蛋白阳性Ｌａｎｇｅｒｈａｎｓ细胞的分布、数量及形态改变。结果显示：在有ＨＰＶ感染时，上皮内ＬＣ数量明显少于无感染者。上皮内残留的少数ＬＣ的分布及形态也有改变。结果提示：ＨＰＶ可能通过减少局部的ＬＣ，破坏机体局部的免疫监视系统，并与其他致癌因素协同作用，进而导致食管癌的发生。 |
| 关 键 词： | 食管鳞状细胞癌；人乳头瘤病毒；原位杂交；Langerhans细胞；免疫组织化学 |
THE STUDY OF INTERRELATION BETWEEN HUMAN PAPILLOMAVIRUS INFECTION AND LANGERHANS CELL IN THE CARCINOGENESIS OF ESOPHAGEAL CARCINOMA |
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| Zhang Yunhan ),Li Jing ),Gao Dongling ),Qiao Sijie ),Wen Xiaogang ) ). THE STUDY OF INTERRELATION BETWEEN HUMAN PAPILLOMAVIRUS INFECTION AND LANGERHANS CELL IN THE CARCINOGENESIS OF ESOPHAGEAL CARCINOMA[J]. Journal of Zhengzhou University: Med Sci, 1997, 0(3) | |
| Authors: | Zhang Yunhan ) Li Jing ) Gao Dongling ) Qiao Sijie ) Wen Xiaogang ) ) |
| Affiliation: | Zhang Yunhan 1),Li Jing 1),Gao Dongling 1),Qiao Sijie 2),Wen Xiaogang 1) 1) Department of Pathology,the First Affiliated Hospital,Henan Medical University,Henan Province Key Laboratory of Tumor Pathology,Zhen |
| Abstract: | The interrelation between human papillomavirus (HPV) infection and Langerhans cells (LC) in the carcinogenesis of esophageal carcinoma and the oncogenic mechanism during HPV infection were studied in this study.Digoxigenined HPV DNA probes of HPV 6B/11,HPV 16/18 and anti s 100 protein antibody were used respectively to investigate the HPV infection and LC with in situ hybridization (ISH) and the immunohistochemical LSAB technique in 40 cases of esophageal squamous cell carcinoma (ESCC).The results showed that there were fewer LCs in the HPV positive cases than those in the HPV negative ones,and even there was nearly not any in the HPV infected foci.The morphological and distributive changes of the LCs in the HPV infected ep ithelia adjacent to cancer also happened.Our results indicate that HPV infection may decrease the number of the local LCs,destroy the local immune surveillance system,and cooperate with other carcinogenic factors,in favor of the development of ESCC. |
| Keywords: | esophageal squamous cell carcinoma human papillomavirus in situ hybridization Langerhans cell immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ | |