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| 瘦素受体及神经肽Y mRNA在肥胖大鼠下丘脑弓状核的表达 | |
| 引用本文： | 曲伸,邹大进. 瘦素受体及神经肽Y mRNA在肥胖大鼠下丘脑弓状核的表达[J]. 中华内分泌代谢杂志, 2003, 19(3): 210-211 |
| 作者姓名： | 曲伸 邹大进 |
| 作者单位： | 200433,上海,第二军医大学附属长海医院内分泌科 |
| 摘 要： | 以高脂饮食制备肥胖大鼠模型和用寡核苷酸探针在下丘脑弓状核进行原位杂交检测，结果显示肥胖大鼠下丘脑弓状核瘦素受体mRNA和神经肽Y mRNA表达明显增加，提示可能为瘦素受体抵抗所致。 |
| 关 键 词： | 瘦素受体 神经肽Y mRNA 肥胖 大鼠 下丘脑弓状核 原位杂交检测 |
| 修稿时间： | 2002-02-11 |
Expressions of leptin receptor mRNA and neuropeptide Y mRNA in the hypothalamic arcuate nucleus of obese rat induced by high fat diet |
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| QU Shen,ZOU Da-jin. Expressions of leptin receptor mRNA and neuropeptide Y mRNA in the hypothalamic arcuate nucleus of obese rat induced by high fat diet[J]. Chinese Journal of Endocrinology and Metabolism, 2003, 19(3): 210-211 | |
| Authors: | QU Shen ZOU Da-jin |
| Affiliation: | QU Shen,ZOU Da-jin,Department of Endocrinology,Changhai Hospital,The Second Military Medical University of PLA,Shanghai 200433 |
| Abstract: | The rat model of obesity was induced by high fat diet and in situ hybridization was performed with oligonucleotide probes.The results showed that expressions of leptin receptor mRNA and neuropeptide Y mRNA were significantly increased, suggesting that these increments might be related to leptin resistance. |
| Keywords: | Neuropeptide Y Receptors leptin Arcuate nucleus |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |