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| 结直肠癌患者肠道微生物多样性的研究进展 | |
| 引用本文： | 武娜,;刘玉兰,;朱元民. 结直肠癌患者肠道微生物多样性的研究进展[J]. 中华临床医师杂志(电子版), 2014, 0(22): 132-135 |
| 作者姓名： | 武娜, 刘玉兰, 朱元民 |
| 作者单位： | [1]北京大学人民医院中心实验室,100044; [2]北京大学人民医院消化内科,100044 |
| 摘 要： | 结直肠癌是最常见的消化道恶性肿瘤之一,其发病原因除了饮食、环境以及遗传因素外,越来越多的证据指向肠道菌群失调与结直肠癌发生发展有密切的关系。许多元基因组学的研究为揭示肠道微生物在结直肠癌发生发展中起到的作用提供了大量科学依据。在这篇综述中,我们会介绍结直肠癌患者肠道微生物多样性的研究进展,并总结结直肠癌发生发展相关的细菌及其研究现状。 |
| 关 键 词： | 结直肠肿瘤 肠道微生物 菌群多样性 |
Diversity of gut microbiota in patients with colorectal cancer |
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| Affiliation: | Wu Na, Liu Yulan, Zhu Yuanmin. (Institute of Clinical Molecular Biology ＆ Central Laboratory, Peking University People＇s Hospital, Beijing 100044, China) |
| Abstract: | Colorectal cancer （CRC） presents a considerable disease burden worldwide. Besides the diet, the environment, and the genetic factors, it is increasingly evident that dysbiosis of gut microbiota plays a role in the pathogenesis of in CRC. The increasing accessibility of microbial metagenomics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. Some specific gut bacteria have been proposed to be associated with the pathogenesis of CRC. In this review, we discussed recent insights into contributions of the microbiota to CRC. We also highlighted newfindings on candidate CRC-potentiating species and current knowledge gaps. |
| Keywords: | Colorectal neoplasms Gut microbiota Bacterial diversity |
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