内蒙古包头地区胆石症危险因素的研究

目的探讨内蒙古包头地区胆石症的危险因素。方法选取2012年1月至2014年1月于内蒙古医科大学第四附属医院和包头市医学院第二附属医院确诊的住院胆石症患者234例作为病例组,选取同期来院体检的排除胆石症的健康体检者241例作为对照组进行病例对照研究,运用单因素分析和多因素非条件Logistic回归分析方法,分析胆石症的危险因素。结果病例组和对照组调查对象的平均年龄分别为(51.45±12.53)岁和(49.50±12.43)岁,两组男性、女性分别为97例、137例和106例、135例,两组年龄和性别均无统计学差异(t=-1.701,P=0.089;χ2=0.311,P=0.577)。多因素分析结果显示,文化程度为大学及以上(OR=0.068),职业为非工人(农民/牧民、脑力劳动者、无业及离退休的OR值分别为0.050、0.111、0.097),较少食用油炸食品(1次/周的OR值为0.378),经常食用新鲜水果(1次/d的OR值为0.308),经常吃早饭(4⁷ d/周的OR值为0.197),经常进行30 min左右的散步(17 d/周的OR值为0.197),经常进行30 min左右的散步(1²次/周、32次/周、3⁴次/周的OR值分别为0.180、0.076),血钙水平升高(OR=0.149)与胆石症的发生呈负相关关系;而经常食用动物内脏(每周3次以上OR值为8.883),22点之后睡觉(OR=5.111),以前饮酒现在不饮酒(OR=4.593),母亲患冠心病(OR=4.725),体重过重(超重、肥胖的OR值分别为4.706、3.264)和血糖水平高(OR=1.418)与胆石症的发生呈正相关关系。结论低学历和肥胖人群可能是胆石症的高危人群,而多食用新鲜水果蔬菜、坚持吃早餐等能降低其发病风险。

Risk factors of cholelithiasis in Baotou,Inner Mongolia population： a case-control study

Objective To investigate the risk factors of cholelithiasis of populations in Baotou, Inner Mongolia. Methods A case-control study was conducted from January 2012 to January 2014 in the Fourth Affiliated Hospital of Inner Mongolia Medical University and the Second Affiliated Hospital of Bao Tou Medical College, including 234 patients with cholelithiasis and 241 health controls without cholelithiasis, univariate analysis and multivariate logistic regression analysis were used for data analysis. Results Mean age of the study group and the control group were（51.45±12.53） and（49.50±12.43） years old. The number of male and female respondents of the study group were 97 and 137, and the number were 106 and 135 in the control group. The distribution of age and gender of two groups was different（t=-1.701, P=0.089 and χ^2=0.311, P=0.577）. Multivariate Logistic regression analysis showed that, cholelithiasis had significantly negative correlation with higher education level（University graduate or higher, OR=0.068）, working as a farmer or a herder（OR=0.050）, working as the white-collar（OR=0.111）, the unemployed and the retired（OR=0.097）, few fry food intake（1 time a week, OR=0.378）, much fresh fruits intake（1 time a day, OR=0.308）, good breakfast habit（4-7 breakfasts a week, OR=0.197）, often taking a 30-minute walk（1-2 times a week, OR=0.180, 3-4 times a week, OR=0.076）, and higher concentration of blood calcium（OR=0.149）. While, much animal giblets intake（3 times a week, OR=8.883）, going to bed after 22 o＇clock（OR=5.111）, past drinking（OR=4.593）, mother having coronary disease（OR=4.725）, being overweight（OR=4.706）, being obesity（OR=3.264）, higher concentration of blood glucose（OR=1.418） were positively associated with cholelithiasis. Conclusion Lower education level and obesity may increase the risk of cholelithiasis, while fresh fruits intake and having breakfast everyday may prevent the development of cholelithiasis.