| HPSEC法测定注射用头孢匹胺钠中聚合物的含量 |
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| 引用本文： | 徐明琴,陈林,张静霞,张春然,王宇驰,李喆宇,吴小林,唐克慧.HPSEC法测定注射用头孢匹胺钠中聚合物的含量[J].国外医药(抗生素分册),2014(3):131-133. |
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| 作者姓名： | 徐明琴 陈林 张静霞 张春然 王宇驰 李喆宇 吴小林 唐克慧 |
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| 作者单位： | 四川抗菌素工业研究所,成都610052 |
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| 摘 要： | 目的建立HPSEC法对头孢匹胺钠中聚合物进行测定。方法采用TSKgelG2000SWXL色谱柱（7．8mmLD×30cm）；检测波长为254nm；以外标法测定聚合物的含量，并与头孢聚合物测定的文献方法进行比较。结果在该条件下头孢匹胺钠和聚合物峰分离良好；本法的定量限（S／N=9）为9ng；检测限（S／N=3）为3ng，本法测定的聚合物含量高于文献方法的结果。结论本方法简便、准确度高、灵敏度高，可有效的测定头孢匹胺钠中聚合物的含量。
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| 关 键 词： | 注射用头孢匹胺钠 聚合物 TSKge1 G2000SWXL凝胶色谱柱 |
Determination of the Polymers in Cefpiramide Sodium for Injection by HPSEC |
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| Xu Ming-qin,Chen Lin,Zhang Jing-xia,Zhang Chun-ran,Wang Yu-chi,Li Ze-yu,Wu Xiao-lin,Tang Ke-hui.Determination of the Polymers in Cefpiramide Sodium for Injection by HPSEC[J].world notes on antibiotics,2014(3):131-133. |
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| Authors: | Xu Ming-qin Chen Lin Zhang Jing-xia Zhang Chun-ran Wang Yu-chi Li Ze-yu Wu Xiao-lin Tang Ke-hui |
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| Institution: | ( Sichuan Industrial Institute of Antibiotics, Chengdu 610052) |
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| Abstract: | Objective To establish a HPSEC method for the determination of the polymer. Methods The analysis was carried out using a TSKgel G2000SWXL chromatography （7.Smm I.D×30cm） . The detection wavelength was 254nm. The content of polymers was determined by external calibration. The method was compared with determination of the document. Results The polymers were completely separated from cefpiramide. LOQ was 9ng. LOD was 3ng. The method is higher than that of the polymer content determination results of the literature. Conclusion This method was simple, accurate, sensitive, reliable and applicable for the determination of the polymers of cefoiramide. |
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| Keywords: | cefpiramide sodium for injection polymers SKgel G2000SWXL gel chromatography column |
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