Induction of ovulation by antiestrogens]

The mode of action of antioestrogens is in blocking oestrogen receptors in the target cell cytoplasm. For this reason they can be used only in cases where basal oestrogen activity is present. We treated two groups of patients with antioestrogens. In the first group (30 patients) with oligomenarrhoe and an ovulatory sterility we had 15 pregnancies. In the second group of 26 patients with amenorrhoe and sterility we had 4 of pregnancies and 12 menstruations. In this very small group a child with enterocoele was born to a 38-years old patient. All other patients' children were normal. Out of 19 pregnancies 4 were completed by early abortion.