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Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche
Affiliation:1. Toronto General Research Institute, University Health Network, Toronto, ON, Canada;2. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;4. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada;5. Vector Institute for Artificial Intelligence, Toronto, ON, Canada;6. Department of Immunology, University of Toronto, Toronto, ON, Canada;7. STTARR Innovation Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada;8. Department of Physiology, University of Toronto, Toronto, ON, Canada;9. Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA;10. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;11. Ted Rogers Centre for Heart Research, Toronto, ON, Canada;12. Peter Munk Cardiac Centre, Toronto, ON, Canada
Abstract:
Keywords:bone marrow niche  monocyte  macrophage colony stimulating factor  MCSF1  endothelial cell  monopoiesis  hematopoeisis  bone development  osteopetrosis  perivascular niche  Ly6Chigh monocytes  Ly6Cnegative monocytes  sinusoid  osteoblast  osteocyte  lipopolysaccharide  LPS  sepsis  macrophage  perivascular stromal cell  LEPR  mesenchymal stromal cell
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