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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection
Affiliation:1. Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA;2. Center for Gastrointestinal Biology, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil;3. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA;4. Department of Biomedicine, University of Basel, 4031 Basel, Switzerland
Abstract:
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  • Keywords:CD8+ T cells  T cell differentiation  CXCR3  CXCL10  LCMV  chronic viral infection  chemokine  TCF-1  T cell exhaustion
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