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| 脑缺血后神经血管保护机制和损伤机制研究进展 | |
| 引用本文： | 陆征宇,董强. 脑缺血后神经血管保护机制和损伤机制研究进展[J]. 中华脑血管病杂志(电子版), 2013, 0(3): 34-40 |
| 作者姓名： | 陆征宇 董强 |
| 作者单位： | [1]复旦大学附属华山医院神经内科,上海200040 [2]上海中医药大学附属岳阳中西医结合医院神经内科,200437 |
| 摘 要： | 脑梗死是致死性疾病之一，发病率高，严重危害人类健康。尽管各方面的研究不断深入，但是目前仍然缺乏有效的神经保护药物，脑梗死的治疗依然是一个非常棘手的问题。本文从内源性保护机制、谷氨酸受体的双向作用、非谷氨酸依赖的钙失衡损伤机制进行综述，进一步阐释脑缺血后神经血管的保护机制和损伤机制，以求突破神经保护研究的传统框架，寻找神经血管保护治疗的新理念和新思路。 |
| 关 键 词： | 卒中 脑缺血 神经保护 脑损伤 神经血管单元 |
Progress of neurovascular protective and destructive mechanism research after focal cerebral ischemia |
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| LU Zheng-yu,DONG Qiang. Progress of neurovascular protective and destructive mechanism research after focal cerebral ischemia[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Version), 2013, 0(3): 34-40 | |
| Authors: | LU Zheng-yu DONG Qiang |
| Affiliation: | 1Department of Neurology, Huashan Hospital, Fudan University. Shanghai 200040, China; 2.Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China |
| Abstract: | With a high incidence rate, cerebral infarction is one of the most devastating diseases worldwide. Although progress has been made to protect the brain from ischemic cell death, still there is few therapeutic option for neuroprotection. The treatment for ischemic stroke remains a vexing public health problem. Here we describe the mechanisms of endogenous neurovascular protection, beneficial and destructive roles of glutamate receptors and glutamate-independent calcium dysregulation. Learning how the brain triggers and implements these protective and destructive measures may advance our quest to treat stroke. |
| Keywords: | Stroke Cerebral ischemia Neuroprotection Brain injury Neurovascular unit |
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