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急性重复缺氧小鼠脑组织中必需微量元素含量的变化
引用本文:史美棠 曾昭辉. 急性重复缺氧小鼠脑组织中必需微量元素含量的变化[J]. 中国病理生理杂志, 1993, 9(3): 426-429
作者姓名:史美棠 曾昭辉
作者单位:首都医学院神经生物学研究室,首都医学院神经生物学研究室,首都医学院神经生物学研究室,首都医学院神经生物学研究室,首都医学院中心实验室,首都医学院中心实验室 北京 100054,北京 100054,北京 100054,北京 100054
基金项目:北京中关村地区联合分析测试中心的资助
摘    要:
本工作以小鼠为对象,用等离子光量计,测定并探讨了急性重复缺氧过程中动物脑组织内12种必需微量元素含量的变化。与正常对照组动物相比,缺氧1、2次动物脑组织中的非溶解态As含量显著下降、溶解态V含量显著升高;急性重复缺氧4次动物饲养2天后,As、Fe、Cu、Cr、Mo、Co、V等元素含量也发生了显著或非常显著的变化。这些变化的生物学意义及其与缺氧耐受的关系有待进一步探讨。

关 键 词:缺氧 微量元素 脑

Changes of essential trace elements contents in mouse brain tissue following acute and repeated exposure to hypoxia
Shi Mei-Tang,Lu Guo-Wei,et al. Changes of essential trace elements contents in mouse brain tissue following acute and repeated exposure to hypoxia[J]. Chinese Journal of Pathophysiology, 1993, 9(3): 426-429
Authors:Shi Mei-Tang  Lu Guo-Wei  et al
Affiliation:Shi Mei-Tang,Lu Guo-Wei,et al Department of Neurobiology,Capital Institute of Medicine,Beijing
Abstract:
The present experiment was carried out on mice.The changes in contentsof 12 essential trace elements in the brain of mice were measured by inductivelycoupled plasma emission following acute and repetitive exposure to hypoxia.Followingrepeat exposure to hypoxia for one or two runs, the contents of non-soluble in brainhomogenats as was notably decreased,while that of the soluble V was markedly increased,when compared with that of normal group.When the animals were fed for two daysafter four runs of hypoxia,the contents of As,Fe,Cu,Co,Cr,B,and V were all signi-ficantly or very significantly changed in comparison with the normal value.Further stu-dies are needed to find out the biological importance of these changes and the relationshipbetween them and hypoxia tolerance.
Keywords:Anoxia  Trace elements  Brain
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