乳腺癌组织中Cerb-B-2、P53表达及意义

目的 探讨Cerb-B-2、P53基因在乳腺癌中的表达与转移及预后的关系。方法采用免疫组织化学（SP法）对乳腺癌Cerb-B-2、P53的表达进行检测。结果 Cerb-B-2阳性率为68．4％，P53阳性率为51．8％。Cerb-B-2、P53基因蛋白的表达与腋窝淋巴结转移有关（P〈0．01），随临床分期的递增和淋巴结转移数目的增多，其阳性表达率随之增加，差异有统计学意义（P〈0．01）。Cerb-B-2与P53在乳腺癌中的表达呈正相关，其共同阳性表达与淋巴结转移差异有统计学意义（P〈0．01）。结论 Cerb-B-2、P53基因参与乳腺癌的发生发展过程；联合检测Cerb-B-2、P53基因蛋白对预测乳腺癌淋巴结转移及判断预后有重要意义。

Expression of Cerb-B-2 and P53 in Primary Breast Carcinoma

Objective To study the expression of oncogenes Cerb-B-2 and P53,and the relationship of two genes with metastasis and prognosis in patients with primary breast carcinoma.Methods The expression of Cerb-B-2 and P53 was detected by immunohistochemical(s-p methods) in 114 cases of breast carcinoma.Results The positive expression of Cerb-B-2 and P53 were 68.4% and 51.8%,respectively,in breast carcinoma,they were correlated with axilliaris lymph node metastasis (P<0.01).The positive rates Cerb-B-2 and P53 increased with the number of lymphnode metastasis and the clinicopathological stage(P<0.01).The expression of Cerb-B-2 and P53 was correlated positively,farthermore,the co-expression of the two genes was significantly rrelated to lymph node metastasis(P<0.01). Conclusion Oncogenes Cerb-B-2 and P53 may play an important role in the development and progression of beast carcinoma.The combined detection of Cerb-B-2 and P53 geneproteins has positive effects on predicting the lymph node metastasis and the prognosis of breast carcinoma.