血浆脑钠肽对围生期心力衰竭的预后评估价值

目的探讨血浆脑钠肽对围生期充血性心力衰竭患者的预后评估价值。方法选择本院2009年1月至2011年1月收治的36例剖宫产终止妊娠后并发急性充血性心力衰竭患者为观察组,同时选择28例剖宫产终止妊娠后无急性充血性心力衰竭患者为对照组,分别于终止妊娠后进行血浆脑钠肽浓度、血液常规、心电图、心脏射血分数检查。结果观察组血浆脑钠肽浓度高于对照组,且观察组的心脏射血分数低于对照组。血浆脑钠肽水平和心脏射血分数呈负相关。在住院期间内,观察组的全因死亡率高于对照组,差异有统计学意义(P<0.05)。结论对围生期合并充血性心力衰竭患者进行血浆脑钠肽浓度检测,是判断患者心功能的重要指标之一,有助于对其预后进行评估,具有临床应用价值。

The value of plasma brain natriuretic peptide in prognosis of perinatal heart failure

Objective To investigate the association between plasma brain natriuretic peptide （BNP） concentration and the prognosis of the patients with perinatal congestive heart failure. Methods From January 2009 to Jan uary 2011,36 cases （defined as observation group） with normal term pregnancy after cesarean section were admitted to our hospital due to acute congestive heart failure,while 28 cases with normal term pregnancy after cesarean section without heart failure were included as control. Patients in both groups underwent physical examination, routine blood biochemical test,ejection fraction estimate and plasma BNP detection. The observation endpoint was the all cause mortality during hospitalization. Results The baseline characteristics appeared similar between two groups, however,the patients in observation group had a significantly lower ejection fraction value and higher BNP level as com pared with control group. The ejection fraction was negatively correlated with the plasma BNP level. During the hos- pitalization, the observation group was observed to have a significantly higher risk of all cause mortality （P〈0.05）. Conclusion For patients with perinatal congestive heart failure,an increased plasma BNP level is associated with a reduced cardiac left ventricular ejection fraction,and it can be used as a predictor of in-hospital mortality.