参芪五味子胶囊镇静、抗应激作用研究

目的:研究参芪五味子胶囊镇静、抗应激的作用。方法:采用戊巴比妥钠阈下剂量及催眠剂量观察参芪五味子胶囊对戊巴比妥钠小鼠催眠的协同作用;采用小鼠游泳、常压下耐缺氧实验观察参芪五味子胶囊对小鼠的抗应激作用。结果:参芪五味子胶囊能显著延长戊巴比妥钠小鼠的睡眠时间,增加阈下剂量戊巴比妥钠入睡小鼠只数;显著延长小鼠游泳时间和耐缺氧时间。结论:参芪五味子胶囊具有镇静、抗应激的作用。

Sedative and Anti - stress Action of Shenqiwuweizi Capsule

OBJECTIVE： To study the sedative and antistress action of Shenqiwuweizi capsule. METHODS： The sedative and hypnotic experiments were made to observe the action of Shenqiwuweizi capsule on the mice＇s sleep induced by pentobarbital sodium at subthreshold dosage or hypnotic dosage. The swimming and hypoxia tolerance experiment were performed to observe the effects of Shenqiwuweizi capsule on the swimming time and hypoxia tolerance time in mice. RESULTS： Shenqi- wuweizi capsule could obviously prolong the sleeping time of mice induced by pentobarbital sodium, increase the number of sleeping animals caused by pentobarbital sodium at subthreshold dosage, and significantly prolong the time of swimming and hypoxia tolerance in mice. CONCLUSION： Shenqiwuweizi capsule had sedative and antistress action.