Association of RGS2 variants with panic disorder in a Japanese population |
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| Authors: | Takeshi Otowa Takafumi Shimada Yoshiya Kawamura Nagisa Sugaya Eiji Yoshida Ken Inoue Shin Yasuda Xiaoxi Liu Takanobu Minato Mamoru Tochigi Tadashi Umekage Kiyoto Kasai Hisashi Tanii Yuji Okazaki Hisanobu Kaiya Tsukasa Sasaki |
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| Affiliation: | 1. Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia;2. Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan;3. Faculty of Human Science, Waseda University, Tokorozawa, Saitama, Japan;4. Outpatient Clinic for Anxiety Disorders, Akasaka Mental Clinic, Minato, Tokyo, Japan;5. Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi, Japan;6. Department of Neuropsychiatry, Graduate School of Medicine, Mie University, Tsu, Mie, Japan;7. Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan;8. Department of Neurology, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan;9. Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Aichi, Japan;10. Health Service Center, University of Tokyo, Bunkyo, Tokyo, Japan;11. Office for Mental Health Support and Graduate School of Education, University of Tokyo, Bunkyo, Tokyo, Japan |
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| Abstract: | Panic disorder (PD) is a severe and chronic psychiatric disorder with significant genetic components underlying its etiology. The gene regulator of G protein signaling 2 (RGS2) has been reported to be associated with anxiety disorders. To confirm the association of RGS2 with PD, we investigated three single nucleotide polymorphisms (SNPs) of RGS2 (rs10801152, rs4606, and rs1819741) in 677 Japanese PD cases and 460 controls. The SNP rs10801152 was suggestive of an association with PD (allele P = 0.045 adjusted using sex and age as confounding factors). The three‐SNP haplotype was significantly associated with PD (global permutation P = 4 × 10?4). The haplotypes T‐G‐C and T‐C‐T showed significant association and protective effect on PD (T‐G‐C, permutation P = 0.038, OR = 0.80, 95%CI = 0.68–0.95; T‐C‐T, permutation P = 0.004, OR = 0.38, 95%CI = 0.21–0.70). These results provide support for an association of RGS2 with PD in a Japanese population. © 2011 Wiley‐Liss, Inc. |
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| Keywords: | panic disorder regulator of G protein signaling 2 (RGS2) single nucleotide polymorphism association Japanese population |
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