多发性抽动症患儿的智力和记忆结构缺陷及其胃复安治疗后的对比研究

目的 :了解多发性抽动症 (TS)患儿的智力和记忆结构情况 ,并探讨胃复安对其智力和记忆功能的影响。方法 :采用韦氏儿童智力量表 (C WISC)和韦氏儿童记忆量表甲式 (WMS CR)对 5 5例 (未用药组 30例和用药组 2 5例 )TS患儿的智力和记忆功能进行测试 ,并与 2 0例正常对照组儿童比较。结果 :智力测验中 ,未用药组的TS患儿的记忆 不分心因子存在一定缺陷 ,而服用胃复安组后记忆 不分心因子方面的缺陷得到改善 ,知觉组织因子能力进一步提高。记忆测验中 ,未用药组TS患儿的短时记忆和瞬间记忆有缺陷 ,且可能还存在一定程度长时记忆缺陷 ,而胃复安很可能对患儿的短时记忆功能有一定的改善。结论 :胃复安对TS患儿智力水平中的记忆 不分心因子及短时记忆功能均有一定程度的改善

Defect of intelligence and memory of children with Tourette syndrome and the treatment of metoclopramide

Objective To investigate the defect of intelligence and memory in children with Tourette syndrome and the role of metoclopramide. Methods The intelligence and memory of 55 children with Tourette syndrome (including 30 children who had received the treatment of metoclopramide) were evaluated by the Wechsler intelligence scale for children (WISC) and WMS CR, while those of 20 normal children were evaluated as controls. Results There was no significant difference in the scores of the performance intelligence quotient (IQ) and verbal IQ between the patients and controls. The short term memory defect in the children without the treatment of metoclopramide was more obvious, either compared with the patients treated by metoclopramide (P<0.05) or compared with the normal children (P<0.01). The difference in attention defect was also significant (P<0.05) among the groups of patients with or without treatment. Conclusion Metoclopramide can decrease the defect of short term memory and attention in children with Tourette syndrome.