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| 羟基喜树碱的油/水分配系数与大鼠小肠吸收的相关性研究 | |
| 引用本文： | 索绪斌,李慕玲,王玉强,朱盛山. 羟基喜树碱的油/水分配系数与大鼠小肠吸收的相关性研究[J]. 中成药, 2010, 32(4): 566-569 |
| 作者姓名： | 索绪斌 李慕玲 王玉强 朱盛山 |
| 作者单位： | 广东药学院中药开发研究所;暨南大学药学院; |
| 基金项目： | 广东药学院“重点培养青年教师”基金(200809052) |
| 摘 要： | 目的:探讨在不同pH值条件下羟基喜树碱的油/水分配系数与大鼠小肠吸收之间的相关性。方法:缓冲溶液水相pH值依次为2.2、4.0、6.0、7.4、9.16及11,正辛醇为油相,采取"摇瓶法"使药物在油相/水相中达到平衡后,用高效液相测定油/水相中药物的浓度,计算药物的油/水分配系数。以酚红为体积校正剂,测定不同pH值条件下,大鼠小肠吸收系数。将药物油/水分配系数与大鼠小肠吸收系数进行线性回归。结果:药物的油/水分配系数与大鼠小肠吸收系数随分散介质的pH值不同而改变,两者之间的线性关系为:y=0.001 3x+0.009 1,相关系数R2为0.959 7。结论:羟基喜树碱的油/水分配系数与小肠吸收之间存在良好的线性关系,可以油/水分配系数预测大鼠小肠吸收。 |
| 关 键 词： | 羟基喜树碱 油/水分配系数 小肠吸收 |
Study on the relativity of oil/water partition coefficient of hydroxycamptothecin and its absorption coefficiency in small intestines of rats |
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| SUO Xu-bin,,LI Mu-ling,WANG Yu-qiang,ZHU Sheng-shan. Study on the relativity of oil/water partition coefficient of hydroxycamptothecin and its absorption coefficiency in small intestines of rats[J]. Chinese Traditional Patent Medicine, 2010, 32(4): 566-569 | |
| Authors: | SUO Xu-bin LI Mu-ling WANG Yu-qiang ZHU Sheng-shan |
| Affiliation: | SUO Xu-bin1,2,LI Mu-ling2,WANG Yu-qiang2,ZHU Sheng-shan1(1.Institute of New Drugdevelopment of TCM,Guangdong Pharmaceutical College,Guangzhou 51006,China,2.School of Pharmacy,Jinan University,Guangzhou 510632,China) |
| Abstract: | AIM: To explore the correlativity of the oil/water partition of hydroxycamptothecin and its absorp-tion coefficiency in small intestine in rats.METHODS: pH value of water phase in buffer solution in turn took 2.2,4.6,7.4,9.6 and 11,while octanol was adopted as oil phase.After phase equilibrium,HPLC was used to determine the concentration of hydro-xycamptothecin,and oil/water partition coefficient was calculated with the phenol red as volume calibration agent,small intestinal absorption coefficients of rats ... |
| Keywords: | hydroxycamptothecin partition coefficient of oil/water absorption in small intestine |
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