| 鹿茸及其有效成分对小鼠脑单胺氧化酶的抑制作用 |
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| 引用本文： | 陈晓光,王本祥,吴延东. 鹿茸及其有效成分对小鼠脑单胺氧化酶的抑制作用[J]. 中药药理与临床, 1990, 0(5) |
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| 作者姓名： | 陈晓光 王本祥 吴延东 |
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| 作者单位： | 吉林省中医中药研究院药理室，吉林省中医中药研究院药理室，吉林省中医中药研究院药理室 长春 130021，长春 130021，长春 130021 吉林省东丰制药厂 |
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| 摘 要： | 体外实验证明,从鹿茸氯仿提取物中分离的石油醚不溶部分(部位Ⅶ)鼠脑MAO-B活性具有显著的抑制作用,但对MAO-A活性抑制不明显。石油醚可对小溶部分(部位Ⅵ)对MAO-B活性无明显的影响。
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| 关 键 词： | 鹿茸 单胺氧化酶 |
The inhibitory Effect of Pilcse Antler and Its Efficacious Ingredients on Monoamine Oxidase Activity |
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| Chen Xiaoguang,wang Benxiang and Wu Yandong. The inhibitory Effect of Pilcse Antler and Its Efficacious Ingredients on Monoamine Oxidase Activity[J]. Pharmacology and Clinics of Chinese Materia Medica, 1990, 0(5) |
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| Authors: | Chen Xiaoguang wang Benxiang Wu Yandong |
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| Abstract: | This paper has reported that the inhibitory effects of the extract from pilose antler on monoamine oxidase B(MAO-B) activty in mouse brain in vitro. It was demonstrated that the petroleum ether insoluble section (Fraction VII) possessed high potency for inaibitiag the activity of MAO-B in the brain mitochondrial preparation in vitro, and low potency for inhibiting the activity of MAO-A. The effect was specific to the B type enzyme of MAO.In addition, the petroleum ether soluble section (Fraction VI) showed slight inhitbitory effect on MAO-B activity. These results suggested that VII was the main active fraction for inhibiting MAO-B activity in pilose antler. |
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| Keywords: | Pilose antler Monoamine oxidase |
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