老年男性的睾酮替代疗法

男性正常衰老过程伴随血清睾酮水平下降 ,但是尚不清楚它是否将导致许多男性的睾酮缺乏症。过去 10年中 ,越来越多的研究兴趣转向确认对那些睾酮缺乏的老年男性采用睾酮替代疗法 (TRT)是否有助于阻止或逆转衰老的某些方面。TRT有益效应相关的主要雄性激素靶器官包括 :骨、肌肉、脂肪组织、心血管系统和脑。与此同时 ,TRT对靶器官 (如前列腺 )的潜在不良反应仍需评估。本文的目的是总结有关老年男性TRT问题的最新认识。

Testosterone Replacement Therapy in Older Men

Normal aging in men is accompanied by a decline in serum levels of testosterone, but whether this will result in many men having symptoms of testosterone deficiency is not certain. Over the past decade, there has been an increasing interest in ascertaining if testosterone replacement therapy (TRT) in older men, who may be testosterone deficient, might be beneficial in preventing or reversing some aspects of aging. The major androgen target organs of interest in regards to beneficial effects of TRT include bone, muscle, adipose tissue, the cardiovascular system and the brain. At the same time, potential adverse effects of TRT on target organs such as the prostate continue to be evaluated. It is the purpose of this review to summarize the current state of knowledge on the issue of TRT for the older man.