血清PTX3在肝细胞癌中的表达及临床意义

目的 探讨血清PTX3在肝细胞癌患者中的表达及临床意义。方法 选择78例肝癌患者作为肝癌组，同时选择健康体检者78例作为健康对照组，检测并比较两组PTX3水平差异，分析不同病理特征患者PTX3水平差异，并采用ROC曲线分析血清PTX3对肝癌的辅助诊断价值。结果 肝癌组患者血清中PTX3水平高于健康对照组（P<0.05）。肝癌患者Ⅰ期组血清PTX3水平高于Ⅱ期组及Ⅲ期组（P<0.05）。肿瘤直径≥5 cm患者血清中PTX3水平明显低于肿瘤直径<5 cm患者（P<0.05）；此外，合并HBV感染的肝癌患者血清中PTX3水平高于无HBV感染的患者（P<0.05）。血清PTX3水平肝癌诊断的ROC曲线下面积为0.938。结论 肝癌患者血清PTX3表达水平显著升高，对肝癌有一定辅助诊断价值。

Expression and Clinical Significance of Serum PTX3 in Hepatocellular Carcinoma

Objective To investigate the expression and clinical significance of serum PTX3 in HCC patients. Methods We selected 78 HCC patients as the liver cancer group, and 78 cases of healthy subjects as the healthy control group. The PTX3 levels were detected and compared between the two groups. The differences of PTX3 levels in patients with different pathological characteristics were analyzed. ROC curve was used to analyze the auxiliary diagnostic value of serum PTX3 in HCC. Results PTX3 level in HCC patients was higher than that in healthy control group (P<0.05). PTX3 level in stage Ⅰ group was higher than those in the stage Ⅱ group and Ⅲ group (P<0.05). PTX3 level in patients with tumor ≥5cm was significantly lower than that with tumor diameter <5cm (P<0.05). In addition, PTX3 level in patients with HBV infection was significantly higher than that without HBV infection (P<0.05). The AUC was 0.938. Conclusion The serum PTX3 level is significantly increased in patients with HCC. It has auxiliary diagnostic value for HCC.