非小细胞肺癌合并2型糖尿病患者的生存状况及影响因素分析

目的:观察非小细胞肺癌合并2型糖尿病患者的生存状况，分析可能影响患者生存状况的因素。方法:采用回顾分析的方法，收集我院2014年8月至2016年8月住院接受治疗的非小细胞肺癌合并2型糖尿病患者200例临床资料，总随访时间为5年，随访期间记录患者生存状况，将死亡者纳为死亡组，将其他患者纳为存活组，对比两组一般情况筛选患者生存状况可能的影响因素，经非条件多项Logistic回归分析找出可能的影响因素。结果:200例患者随访时间为3~5年，中位随访时间为45个月，随访结束时，共死亡168例，死亡率为84.00%。经单因素及多因素分析发现，高龄、病理分期Ⅳ期、入院时卡氏评分（KPS）评分70~80分、血糖波动幅度大、血糖控制效果差均可能是患者死亡主要影响因素（OR＞1，P＜0.05）。结论:非小细胞肺癌合并2型糖尿病患者随着年龄增加、病理分期提高、入院时KPS评分降低、血糖波动幅度增加、血糖控制效果变差，其化疗结束后随访期间死亡风险升高，针对存在上述风险因素者，临床应重视并积极采取防控干预措施，以改善患者生存状况，延长其生存时间。

Analysis of living status and influencing factors of patients with non-small cell lung cancer and type 2 diabetes mellitus

Objective:To observe the living status of patients with non-small cell lung cancer(NSCLC)and type 2 diabetes mellitus(T2DM),and to analyze the influencing factors of living status.Methods:With retrospective analysis method,clinical data of 200 patients were collected from August 2014 to August 2016 in the hospital for treatment of non-small cell lung cancer combined with type 2 diabetes.Total follow-up time was 5 years.During the follow-up period,survival condition was recorded.The dead were included in the death group,and the other patients were included in survival group.The factors affecting patients living conditions were screened.The unconditioned multinomial Logistic regression analysis was used to find out the possible influencing factors.Results:The follow-up time of 200 patients was 3 to 5 years,and the median follow-up time was 45 months.At the end of follow-up,168 patients died and the mortality rate was 84.00%.Single-factor and multiple-factor analysis showed that the advanced age,pathological stage with Ⅳ stage,Karnofsky Performance Status(KPS)with 70~80 points,large fluctuations in blood glucose,and poor glycemic control may be the main influencing factors of death of patient(OR>1,P＜0.05).Conclusion:With the increase of age,increase of pathological stage,decrease of KPS score on admission,increase of blood glucose fluctuation,and aggravation of glycemic control in patients with NSCLC and T2DM,the risk of death during follow-up after chemotherapy is increased.As for patients with above risk factors,the clinic should actively take preventive and control interventions,so as to improve the patients' living status and prolong their survival time.