铈纳米颗粒在辐射领域的研究进展

随着核技术在工业,医学领域等方面应用的迅速发展,人们遭受辐射损伤的可能性也随之增加。辐射损伤防治药物是救治与防护辐射损伤最为有效和直接的手段,但目前的辐射损伤防治药物作用效果有限。铈纳米材料因独特的价态结构,使其具有多种酶学模拟活性和可再生性,体现出优越的抗氧化性,强大的清除自由基功能,可以保护细胞免受辐射损伤,可作为理想的辐射防护剂,并应用于多种生物学领域。对相关文献进行查阅可知,铈纳米颗粒的抗氧化性、高SOD模拟活性、清除自由基能力以及抗辐射能力均源自于Ce³⁺/Ce⁴+相互间的转化、氧空位的形成。本文主要介绍铈纳米颗粒的抗辐射活性基础、辐射防护效应及放疗增敏方面的研究进展,为铈纳米颗粒在辐射方向领域提供理论依据与参考。

Research progress of ceria nanoparticles in the field of radiation

With the rapid development of nuclear technology in the fields of industry and medicine, the possibility of people suffering from radiation damage has also increased. Radiation injury prevention and treatment drugs are the most effective and direct means for the treatment and protection of radiation injury, but the current radiation injury prevention and treatment drugs have limited effects. Due to the unique valence structure of cerium nanomaterials, it has a variety of enzymatic simulation activities and reproducibility. It shows superior oxidation resistance, powerful free radical scavenging function, and can protect cells from radiation damage. It can be used as an ideal it is a radioprotective agent, and is used in a variety of biological fields. A review of relevant literature shows that the antioxidant properties, high SOD mimicking activity, free radical scavenging ability and radiation resistance of ceria nanoparticles are derived from the mutual conversion of Ce³⁺/Ce⁴⁺ and the formation of oxygen vacancies. This article mainly introduces the basis of anti-radiation activity of ceria nanoparticles, radiation protection effects and the research progress of radiotherapy sensitization, and provides theoretical basis and reference for ceria nanoparticles in the field of radiation direction.