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| G蛋白偶联受体在糖尿病视网膜病变发病过程中的作用 | |
| 引用本文： | 李艳,利虹瑛,张梦圆,姚勇,蔡季平,谢田华,邵珺. G蛋白偶联受体在糖尿病视网膜病变发病过程中的作用[J]. 眼科新进展, 2021, 0(7): 680-683. DOI: 10.13389/j.cnki.rao.2021.0141 |
| 作者姓名： | 李艳 利虹瑛 张梦圆 姚勇 蔡季平 谢田华 邵珺 |
| 作者单位： | 214023 江苏省无锡市，南京医科大学附属无锡人民医院眼科 |
| 摘 要： | 糖尿病视网膜病变(DR)是糖尿病微血管病变表现之一,也是全球范围内视力丧失的主要原因.目前,临床上主要通过玻璃体内注射抗血管内皮生长因子药物治疗DR,但是部分患者会出现耐受性和不良反应,寻找新的治疗靶点和药物迫在眉睫.G蛋白偶联受体(G protein-coupled receptors,GPCR)是人体内最大的膜受体... |
| 关 键 词： | 糖尿病视网膜病变 G蛋白偶联受体 G蛋白 微血管病变 |
Role of G protein coupled receptors in the pathogenesis of diabetic retinopathy |
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| LI Yan,LI Hongying,ZHANG Mengyuan,YAO Yong,CAI Jiping,XIE Tianhua,SHAO Jun. Role of G protein coupled receptors in the pathogenesis of diabetic retinopathy[J]. Recent Advances in Ophthalmology, 2021, 0(7): 680-683. DOI: 10.13389/j.cnki.rao.2021.0141 | |
| Authors: | LI Yan LI Hongying ZHANG Mengyuan YAO Yong CAI Jiping XIE Tianhua SHAO Jun |
| Affiliation: | Department of Ophthalmology, Wuxi People’s Hospital, Nanjing Medical University, Wuxi 214023, Jiangsu Province, China |
| Abstract: | Diabetic retinopathy (DR) is one of the manifestations of diabetic microangiopathy and the main cause of vision loss worldwide. At present, clinical treatment is mainly through intravitreal injection of anti-vascular endothelial growth factor drugs, but some patients will experience tolerance and adverse reactions. It is urgent to find new therapeutic targets and drugs. G protein-coupled receptors (GPCR) are the largest family of membrane receptor proteins in the human body and play an important role in cell signal transduction. More and more studies have shown that GPCR is involved in the pathophysiological process of DR. This article reviews the role of GPCR in the pathogenesis of DR. |
| Keywords: | diabetic retinopathy G protein coupled receptor G protein microangiopathy |
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