| 外泌体在血液肿瘤微环境中的作用及其诊治意义 |
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| 引用本文： | 南映瑜,姚璇,杨忠.外泌体在血液肿瘤微环境中的作用及其诊治意义[J].肿瘤防治研究,2021,48(1):93-97. |
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| 作者姓名： | 南映瑜 姚璇 杨忠 |
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| 作者单位： | 1. 400038 重庆，重庆大学附属肿瘤医院血液肿瘤科；2. 400038 重庆，陆军军医大学药学与检验医学系临床血液学教研室 |
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| 摘 要： | 外泌体是细胞外囊泡的一类主要成分，是正常生理情况下组织细胞间信号传递的重要介质；在多种血液肿瘤研究中发现外泌体是骨髓微环境各成分间相互作用的关键载体，由于其广泛存在并含有特定的核酸、蛋白等分子，外泌体被作为潜在的生物标志物和治疗靶点/载体，在血液肿瘤诊治中的重要性近年正逐步受到关注。
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| 关 键 词： | 外泌体 微环境 血液肿瘤 诊断 治疗 |
| 收稿时间： | 2020-06-05 |
Role of Exosome in Microenvironment of Hematological Malignancies and Its Diagnostic and Therapeutic Potential |
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| NAN Yingyu,YAO Xuan,YANG Zhong.Role of Exosome in Microenvironment of Hematological Malignancies and Its Diagnostic and Therapeutic Potential[J].Cancer Research on Prevention and Treatment,2021,48(1):93-97. |
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| Authors: | NAN Yingyu YAO Xuan YANG Zhong |
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| Institution: | 1. Department of Hematological Oncology, Chongqing University Cancer Hospital, Chongqing 400038, China; 2. Department of Clinical Hematology, Faculty of Laboratory Medicine, Army Medical University, Chongqing 400038, China |
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| Abstract: | Exosome, a major component of extracellular vesicles, is an important media for intercellular communications under physiological conditions. In a variety of hematological malignancies researches, it has been demonstrated that exosome acts as the key carrier for interactions among the components of the bone marrow microenvironment. Due to its widespread existence and containing specific nucleic acid and protein molecules, the importance of exosome as a potential biomarker and therapeutic target/carrier in the diagnosis and treatment of hematological malignancies has been attracting more attention in the past few years. |
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| Keywords: | Exosome Microenvironment Hematological malignancies Diagnosis Therapy |
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