精神分裂症患者治疗依从性的相关因素分析

  目的  调查并分析影响精神分裂症患者治疗依从性的相关因素，为临床制定干预措施提供参考依据。  方法  选取金华市第二医院精神科2019年1月—2020年12月收治的150例康复期精神分裂症患者，运用Morisky用药依从性问卷(MMAS-8)对其治疗依从性进行调查，将治疗依从性好者纳入研究组，将治疗依从性差者纳入对照组，比较2组一般资料的差异，运用logistic分析法分析治疗依从性的影响因素。  结果  150例患者中，完全依从73例，部分依从43例，不依从34例，治疗依从性好者116例(77.33%)，治疗依从性差者34例(22.67%)；2组患者文化水平(χ2=4.005，P=0.045)、病程(t=3.505，P＜0.001)、治疗费用(t=6.179，P＜0.001)、住院时间(t=4.165，P＜0.001)、疾病知识掌握度(χ2=7.273，P=0.007)、复诊情况(χ2=4.193，P=0.041)、副反应量表(TESS)评分(t=12.592，P＜0.001)与简明精神病评定量表(BPRS)评分(t=20.250，P＜0.001)比较，差异均有统计学意义；logistic分析显示，文化水平低、TESS评分≥30分、BPRS评分＞35分是影响治疗依从性的危险因素，住院时间≥45 d、疾病知识掌握度好、定期复诊是治疗依从性的保护因素。  结论  影响精神分裂症患者治疗依从性的相关因素较多，其中TESS、BPRS评分越低则患者治疗依从性越高。 

Analysis of related factors of treatment compliance in patients with schizophrenia

  Objective  To investigate and analyse the related factors of treatment compliance in patients with schizophrenia and provide reference for clinical intervention.  Methods  A total of 150 cases of convalescent schizophrenic patients who were treated in our hospital from January 2019 to December 2020 were selected, and their treatment compliance was investigated by using the Morisky medication compliance questionnaire (MMAS-8). Logistic regression analysis was used to analyse the influencing factors of treatment compliance.  Results  Amongst the 150 patients, 73 cases of complete compliance, 43 cases of partial compliance, 34 cases of non-compliance, 116 cases (77.33%) of good treatment compliance and 34 cases (22.67%) of poor treatment compliance were identified. The level of education, course of disease, treatment cost, length of hospital stay, mastery of disease knowledge, return visit, treatment emergent symptom scale (TESS) score and brief psychiatric rating scale (BPRS) score were compared between the two groups, and the difference was statistically significant (χ2=4.005, P=0.045; t=3.505, P < 0.001; t=6.179, P < 0.001; t=4.165, P < 0.001; χ2=7.273, P=0.007; χ2=4.193, P=0.041; t=12.592, P < 0.001; t=20.250, P < 0.001). Multivariate logistic regression analysis showed that the level of education, low educational level, Tess score ≥ 30 and BPRS score > 35 are the risk factors affecting treatment compliance. Hospitalization time ≥ 45 days, good mastery of disease knowledge and regular follow-up are the protective factors of treatment compliance.  Conclusion  Several factors influencing the treatment compliance of schizophrenic patients are identified. The TESS and BPRS scores are inversely proportional to treatment compliance, the lower the score, the higher the treatment compliance.