PCNA和CEA在甲状腺癌中的表达

目的 :分析甲状腺癌增殖细胞核抗原 (PCNA)、胚胎性抗原 (CEA)表达情况 ,提供临床预后参考。方法 :采用S P法免疫组织化学技术 ,以石蜡包埋切片免疫染色。结果 :2 8例甲状腺癌患者组织学类型的PCNA ,乳头状癌 、 分别为 66.67%和 33.33% ;滤泡状癌分别为 4 2 .86%和 57.14% , 均为0。髓样癌 和 分别为 66.67%和 33.33% ,未分化癌为 33.33%和 66.67%。CEA的阴性率为2 8 57% ,阳性率为 71 4 3% ,其中 和 占 85% , 占 15% ,15%中主要为髓样癌和未分化癌的组织学类型。结论 :甲状腺癌的恶性程度与PCNA、CEA表达强度有密切关系。检测PCNA、CEA表达强度作为判断甲状腺癌的恶性程度及评估预后 ,具有临床的实际意义 ,可提供治疗参考价值

The Expression of PCNA and CEA in Thyroid Cancer

Objective To analyze the expression of proliferative cell nuclear antigen(PCNA), carcinoembry-onic antigen (CEA) in thyroid cancer of clinical pronosis. Methods Paraffin embedding slides were stained byS-P immunohistochemistry. Results Among 28 thyroid carcinama cases, the positive rates were as fellows:papillary carcinoma cancer + ,++ were 66.67% and 33.33% ;Follicula cancer were 42.86% and 57.14% ,+++was 0;Medullary cancer ++,+++were 66.67% and 33.33% ;Undifferentiated cancer were 33.33% and 66.67% .The negative rate of CEA was 28.57% ,the positive rate was 71.43% ,among which 85% were + and++,15% was +++, the histological types of the latter were mainly mudullary cancer and undifferentiated histologytype. Concluslons The maliganant degree of thyroid carcinama has close relations with the expression intensi-ty of PCNA and CEA. Testing its expression intensity has clinical and practical significance. It can provide ref-erence in treatment.