静脉注射不同剂量异丙酚对血流动力学及通气功能的影响

应用阻抗法和分气流监测法观察静脉注射不同剂量异丙酚（Ｐｒｏｐｏｆｏｌ，ＰＲＯ）后患者血流动力学（ＭＡＰ、ＮＲ、ＳＬＣＩ、ＩＦＩ、ＶＥＴ、ＥＶＩ、ＳＶＲＩ、ＩＣ、ＰＦＩ、ＬＳＷＩ）与通气功能（ＶＴ、ＲＲ、ＶＥ、ＦＥＶ１％、ＥＴＣＯ２、ＳＰＯ２、 Ｉ－ＥｔＯ２）的变化。 ４０例（ＡＳＡⅠ～ Ⅱ）随机分成四组，ＰＲＯ剂量分别为 １．０ｍｇ／ｋｇ、１．５ｍｇ／ｋｇ、２．０ｍｇ／ｋｇ、２．５ｍｇ／ｋｇ。结果：（１）１～４组呼吸暂停发生率为０％、２０％、３０％、８０％，苏醒时间分别为３ ０±１．５、７．４±２．３、９．１±３．６、９．６±４．２分钟：（２）静脉注射不同剂量ＰＲＯ启ＳＡＰ、ＤＡＰ、ＭＡＰ、ＳＩ下降，ＨＲ、ＣＩ、ＳＶＲＩ无明显变化，心肌收缩性（ＩＣ、ＰＦＩ、ＥＶＩ）明显减弱，ＳＶＲＩ减少；（３）ＰＲＯ对呼吸有抑制作用，以ＶＴ和ＶＥ影响最大，与剂量呈正相关；对面罩吸氧患者ＳｐＯ２、ＲＲ、ＥＴＣＯ２无明显改变，Ｉ－ＥｔＯ２减少；舌后坠者托起下颌对ＶＴ、ＶＥ的恢复颇为有效。

Effects of hemodynamic and respiration after administration of different propofol doses in surgical patients

Changes of hymodynamic indices, including HR, MAP, SI, CI, TFI, VET, EVI, SVRI, IC, PEI, LSWI, and ventilatory function indices, Including Vt, VE, RR, FEV1 %, ETCO2, SPO2, I-EtO2 after intravenous propofol were studied with BoMed NCCOM3 and Datex ULTIMA. Fourty surgical patients (ASA ~ )were alocated into four groups. The doses of propofol used in four groups were 1. 0mg/kg, 1. 5mg/kg, 2. 0mg/kg, 2. 5mg/kg respectively. The results showed that: 1 )The rate of apnea were 0 %, 20 %, 30 % and 80%,and the time of conscious recovery were 3. 0 1. 5, 7. 4 2. 2, 9. I 3. 6, 9. 6 4. 2 minutes in four groups respectively ; 2 )After intravenous administration of differnt doses of propofol, SAP, DAP, MAPand SI decreased, LSWI, IC, PFI,EVI reduced (P < 0. 5~0. 01 ),with no obvious change of HR,CI and SVRI (P>0. 05 ) ; 3)Ventilatory function may be depressed after intravenous propofol. The changes of Vt and VE were most significant within the indices and I-EtO2 reduced (P