极低出生体重儿预防性抗真菌治疗的临床意义

目的探讨极低出生体重儿（very low birthweight infant，VLBWI）抗真菌治疗的临床意义与疗效。方法以我科2003—2007年收治的VLBWI为研究对象，在患儿持续使用抗生素大于2～3周时给予预防性静脉抗真菌治疗（氟康唑氯化钠注射液4mg／kg·d，用2d停1d，疗程2周），观察患儿病情转归情况，监测肝、肾功能及血象情况。结果患儿病情进展较顺利，无1例出现肝、肾功能损害等副作用。结论VLBWI适时给予预防性静脉抗真菌治疗具有重要的临床意义，而且安全性较好，无明显副作用。

Clinical Significance and Efficacy of Preventive Anti-Fungal Treatment in Very-Low Birth-Weight Infant

Objective To evaluate the clinical significance of the preventive anti-fungal treatment in the prevention of fungal infection in very-low birth-weight infant. Method Very-low birth-weight infants admitted to this hospital from 2003 to 2007 were studied. Preventive anti-fongal treatment （Fluconazol 4 mg/kg/d for 2 days, followed by 1 day rest, this cycle was repeated for 2 weeks） was given to the very-low birth-weight infants receiving antibiotics for more than 2 to 3 weeks. Haematological data, liver and kidney functions were monitored after the preventive treatment. Result Side effects such as liver and kidney function failure were not observed. Conclusion Preventive anti-fungal treatment is safe in the very-low birth-weight infants.