Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies |
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| Authors: | Wei Hao You-Yang Shi Yue-Nong Qin Chen-Ping Sun Li-Ying Chen Chun-Yu Wu Yi-Jia Bao Sheng Liu |
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| Affiliation: | a Department of Breast Surgery (Integrated Traditional and Western Medicine), Long Hua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;b Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
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| Abstract: | Background:To assess the benefits and harmful effects of Chinese herbal medicine (CHM) formulations in preventing anthracyclines (ANT)-induced cardiotoxicity.Method:The Cochrane Library, Pubmed and EMBASE databases were electronically searched for relevant randomized controlled trials (RCTs) published till December 2021 in English or Chinese-language, in addition to manual searches through the reference lists of the selected papers, and the Chinese Conference Papers Database. Data was extracted by 2 investigators independently.Result:Seventeen RCTs reporting 11 different CHMs were included in this meta-analysis. The use of CHM reduced the occurrence of clinical heart failure (RR 0.48, 95% CI 0.39 to 0.60, P < .01) compared to the control group. Data on subclinical heart failure in terms of LVEF values showed that CHM reduced the occurrence of subclinical heart failure (RR 0.47, 95% CI 0.35 to 0.62, P < .01) as well.Conclusion:CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious. |
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| Keywords: | anthracycline cancer cardiotoxicity Chinese herbal medicine meta-analysis |
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