Inappropriate peripheral blood lymphocyte responses to herpes viruses in patients with behçet's syndrome |
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| Authors: | J Efthimiou M K Harikumar R A Knight M L Snaith |
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| Affiliation: | Department of Medicine and Rheumatology, University College London, Rayne Institute, University Street, London WCIE 6JJ, U.K. |
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| Abstract: | ![]()
Specific antibody production and the proliferative response of peripheral blood lymphocytes (PBLs) to a variety of viruses, including herpes simplex virus-type-1 (HSV-1) and varicella zoster (VZ), were studied in 7 patients with Behçet's syndrome. None of the patients produced an antibody response against HSV-1 or VZ. Furthermore, none of the patients showed a proliferative response to VZ, and three of them also failed to mount a response to HSV-I. These results suggest that the PBLs of patients with Behçet's syndrome make an inappropriately poor antibody and proliferative response when stimulated by HSV-1 and VZ. |
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| Keywords: | Behçet's syndrome viruses peripheral blood lymphocyte responses |
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